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| U | Toronto FC | - | CF América | 3:1 (2:1) | ||
| R | CF América | - | Toronto FC | 1:1 (0:1) | ||
| U: 04.04.2018 02:00 | R: 11.04.2018 04:00 | Winnaars: Toronto FC | ||||
| U | Deportivo Guadalajara | - | New York RB | 1:0 (1:0) | ||
| R | New York RB | - | Deportivo Guadalajara | 0:0 (0:0) | ||
| U: 05.04.2018 04:00 | R: 11.04.2018 02:00 | Winnaars: Deportivo Guadalajara | ||||
