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| U | Carabobo FC | - | Guaraní | 1:0 (1:0) | ||
| R | Guaraní | - | Carabobo FC | 6:0 (2:0) | ||
| U: 30.01.2018 23:15 | R: 06.02.2018 23:15 | Winnaars: Guaraní | ||||
| U | Banfield | - | Independiente del Valle | 1:1 (0:0) | ||
| R | Independiente del Valle | - | Banfield | 2:2 (1:1) | ||
| U: 31.01.2018 01:30 | R: 07.02.2018 01:30 | Winnaars: Banfield | ||||
| U | Santiago Wanderers | - | FBC Melgar | 1:1 (1:1) | ||
| R | FBC Melgar | - | Santiago Wanderers | 0:1 (0:1) | ||
| U: 31.01.2018 01:30 | R: 07.02.2018 01:30 | Winnaars: Santiago Wanderers | ||||
| U | Chapecoense | - | Nacional | 0:1 (0:0) | ||
| R | Nacional | - | Chapecoense | 1:0 (1:0) | ||
| U: 01.02.2018 00:45 | R: 08.02.2018 00:45 | Winnaars: Nacional | ||||
| U | Universidad de Concepción | - | Vasco da Gama - RJ | 0:4 (0:2) | ||
| R | Vasco da Gama - RJ | - | Universidad de Concepción | 2:0 (2:0) | ||
| U: 01.02.2018 00:45 | R: 08.02.2018 00:45 | Winnaars: Vasco da Gama - RJ | ||||
| U | Deportivo Táchira | - | Santa Fe | 2:3 (2:2) | ||
| R | Santa Fe | - | Deportivo Táchira | 0:0 (0:0) | ||
| U: 01.02.2018 23:15 | R: 09.02.2018 01:00 | Winnaars: Santa Fe | ||||
| U | Oriente Petrolero | - | Jorge Wilstermann | 1:2 (1:0) | ||
| R | Jorge Wilstermann | - | Oriente Petrolero | 2:2 (2:0) | ||
| U: 02.02.2018 01:30 | R: 09.02.2018 01:30 | Winnaars: Jorge Wilstermann | ||||
| U | Club Olimpia | - | Atlético Junior | 1:0 (1:0) | ||
| R | Atlético Junior | - | Club Olimpia | 3:1 (1:1) | ||
| U: 02.02.2018 01:30 | R: 09.02.2018 03:15 | Winnaars: Atlético Junior | ||||
