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| U | Independiente Medellín | - | Cerro Porteño | 0:0 (0:0) | ||
| R | Cerro Porteño | - | Independiente Medellín | 2:0 (1:0) | ||
| U: 19.10.2016 02:00 | R: 26.10.2016 02:00 | Winnaars: Cerro Porteño | ||||
| U | Atlético Junior | - | Chapecoense | 1:0 (1:0) | ||
| R | Chapecoense | - | Atlético Junior | 3:0 (2:0) | ||
| U: 20.10.2016 01:45 | R: 27.10.2016 01:45 | Winnaars: Chapecoense | ||||
| U | Coritiba - PR | - | Atlético Nacional | 1:1 (0:1) | ||
| R | Atlético Nacional | - | Coritiba - PR | 3:1 (0:1) | ||
| U: 20.10.2016 01:45 | R: 27.10.2016 01:45 | Winnaars: Atlético Nacional | ||||
| U | San Lorenzo | - | Palestino | 2:0 (2:0) | ||
| R | Palestino | - | San Lorenzo | 1:0 (0:0) | ||
| U: 21.10.2016 02:00 | R: 28.10.2016 02:00 | Winnaars: San Lorenzo | ||||
