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| U | Deportivo Guadalajara II | - | Atlas Guadalajara II | 3:2 | ||
| R | Atlas Guadalajara II | - | Deportivo Guadalajara II | 0:0 | ||
| U: 25.04.2018 17:00 | R: 28.04.2018 18:30 | Winnaars: Deportivo Guadalajara II | ||||
| U | Gallos Blancos II | - | UANL Tigres II | 0:1 | ||
| R | UANL Tigres II | - | Gallos Blancos II | 1:2 | ||
| U: 26.04.2018 00:00 | R: 28.04.2018 18:30 | Winnaars: Gallos Blancos II | ||||
| U | Puebla FC II | - | CF América II | 3:1 | ||
| R | CF América II | - | Puebla FC II | 3:2 | ||
| U: 26.04.2018 18:00 | R: 29.04.2018 17:00 | Winnaars: Puebla FC II | ||||
| U | CD Veracruz II | - | Club Necaxa II | 1:0 | ||
| R | Club Necaxa II | - | CD Veracruz II | 5:1 | ||
| U: 27.04.2018 00:00 | R: 29.04.2018 18:00 | Winnaars: Club Necaxa II | ||||
