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| U | UANL Tigres | - | Santos Laguna | 2:2 | ||
| R | Santos Laguna | - | UANL Tigres | 1:1 | ||
| U: 10.05.2018 17:00 | R: 13.05.2018 16:00 | Winnaars: Santos Laguna | ||||
| U | CF Pachuca | - | CF América | 2:2 | ||
| R | CF América | - | CF Pachuca | 0:3 | ||
| U: 10.05.2018 17:30 | R: 13.05.2018 17:00 | Winnaars: CF Pachuca | ||||
