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| 07.04.2006 | 20:00 | VVV-Venlo | - | Go Ahead Eagles | 3:0 (1:0) | |
| 20:00 | FC Omniworld | - | FC Dordrecht | 2:4 (0:2) | ||
| 20:00 | HFC Haarlem | - | MVV Maastricht | 0:0 (0:0) | ||
| 20:00 | Helmond Sport | - | BV Veendam | 0:2 (0:0) | ||
| 20:00 | Stormvogels Telstar | - | AGOVV | 3:1 (2:1) | ||
| 20:00 | TOP Oss | - | FC Volendam | 1:2 (0:0) | ||
| 20:00 | Fortuna Sittard | - | SBV Excelsior | 1:1 (0:1) | ||
| 20:00 | FC Zwolle | - | De Graafschap | 2:3 (1:1) | ||
| 20:00 | SC Cambuur | - | FC Den Bosch | 1:0 (0:0) | ||
| 20:00 | FC Emmen | - | FC Eindhoven | 3:1 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SBV Excelsior | 38 | 22 | 9 | 7 | 68:25 | 43 | 75 |
| 2 |
|
VVV-Venlo | 38 | 20 | 8 | 10 | 53:34 | 19 | 68 |
| 3 |
|
FC Volendam | 38 | 19 | 9 | 10 | 59:43 | 16 | 66 |
| 4 |
|
Helmond Sport | 38 | 19 | 7 | 12 | 62:55 | 7 | 64 |
| 5 |
|
De Graafschap | 38 | 17 | 11 | 10 | 63:51 | 12 | 62 |
| 6 |
|
FC Emmen | 38 | 18 | 6 | 14 | 68:56 | 12 | 60 |
| 7 |
|
FC Den Bosch | 38 | 16 | 11 | 11 | 62:51 | 11 | 59 |
| 8 |
|
HFC Haarlem | 38 | 17 | 8 | 13 | 57:51 | 6 | 59 |
| 9 |
|
FC Dordrecht | 38 | 15 | 11 | 12 | 61:45 | 16 | 56 |
| 10 |
|
AGOVV | 38 | 17 | 5 | 16 | 64:62 | 2 | 56 |
| 11 |
|
TOP Oss | 38 | 15 | 10 | 13 | 51:53 | -2 | 55 |
| 12 |
|
FC Zwolle | 38 | 15 | 9 | 14 | 57:52 | 5 | 54 |
| 13 |
|
MVV Maastricht | 38 | 13 | 12 | 13 | 53:52 | 1 | 51 |
| 14 |
|
BV Veendam | 38 | 14 | 9 | 15 | 54:60 | -6 | 51 |
| 15 |
|
SC Cambuur | 38 | 12 | 14 | 12 | 48:50 | -2 | 47 |
| 16 |
|
Stormvogels Telstar | 38 | 9 | 13 | 16 | 37:53 | -16 | 40 |
| 17 |
|
FC Eindhoven | 38 | 11 | 6 | 21 | 53:65 | -12 | 39 |
| 18 |
|
Go Ahead Eagles | 38 | 8 | 11 | 19 | 45:70 | -25 | 35 |
| 19 |
|
FC Omniworld | 38 | 7 | 8 | 23 | 50:87 | -37 | 29 |
| 20 |
|
Fortuna Sittard | 38 | 2 | 11 | 25 | 35:85 | -50 | 17 |
| Promotie |
