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| 22.02.2019 | 18:30 | 1. FC Union Berlin | - | Arminia Bielefeld | 1:1 (1:0) | |
| 18:30 | SpVgg Greuther Fürth | - | 1. FC Heidenheim 1846 | 0:0 (0:0) | ||
| 23.02.2019 | 13:00 | VfL Bochum | - | Holstein Kiel | 1:3 (0:3) | |
| 13:00 | FC St. Pauli | - | FC Ingolstadt 04 | 1:0 (0:0) | ||
| 13:00 | 1. FC Köln | - | SV Sandhausen | 3:1 (0:1) | ||
| 13:00 | SV Darmstadt 98 | - | Dynamo Dresden | 2:0 (1:0) | ||
| 24.02.2019 | 13:30 | Jahn Regensburg | - | Hamburger SV | 2:1 (0:1) | |
| 13:30 | Erzgebirge Aue | - | MSV Duisburg | 0:0 (0:0) | ||
| 13:30 | 1. FC Magdeburg | - | SC Paderborn 07 | 1:1 (1:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Köln | 23 | 14 | 3 | 6 | 57:29 | 28 | 45 |
| 2 |
|
Hamburger SV | 23 | 13 | 5 | 5 | 31:26 | 5 | 44 |
| 3 |
|
1. FC Union Berlin | 23 | 10 | 11 | 2 | 37:21 | 16 | 41 |
| 4 |
|
FC St. Pauli | 23 | 12 | 4 | 7 | 37:32 | 5 | 40 |
| 5 |
|
Holstein Kiel | 23 | 10 | 9 | 4 | 44:31 | 13 | 39 |
| 6 |
|
1. FC Heidenheim 1846 | 23 | 10 | 9 | 4 | 37:28 | 9 | 39 |
| 7 |
|
SC Paderborn 07 | 23 | 10 | 8 | 5 | 54:36 | 18 | 38 |
| 8 |
|
Jahn Regensburg | 23 | 8 | 9 | 6 | 35:34 | 1 | 33 |
| 9 |
|
VfL Bochum | 23 | 8 | 6 | 9 | 33:34 | -1 | 30 |
| 10 |
|
SpVgg Greuther Fürth | 23 | 7 | 8 | 8 | 24:40 | -16 | 29 |
| 11 |
|
Arminia Bielefeld | 23 | 7 | 7 | 9 | 33:35 | -2 | 28 |
| 12 |
|
Erzgebirge Aue | 23 | 7 | 5 | 11 | 27:29 | -2 | 26 |
| 13 |
|
SV Darmstadt 98 | 23 | 7 | 5 | 11 | 31:40 | -9 | 26 |
| 14 |
|
Dynamo Dresden | 23 | 7 | 5 | 11 | 26:35 | -9 | 26 |
| 15 |
|
1. FC Magdeburg | 23 | 4 | 10 | 9 | 27:38 | -11 | 22 |
| 16 |
|
FC Ingolstadt 04 | 23 | 4 | 7 | 12 | 23:38 | -15 | 19 |
| 17 |
|
SV Sandhausen | 23 | 3 | 8 | 12 | 24:35 | -11 | 17 |
| 18 |
|
MSV Duisburg | 23 | 4 | 5 | 14 | 22:41 | -19 | 17 |
| Promotie | |
| Promotie en degradatie | |
| Promotie en degradatie | |
| Degradatie |
