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| 16.04.2022 | 13:30 | Hannover 96 | - | Fortuna Düsseldorf | 0:0 (0:0) | |
| 13:30 | SV Sandhausen | - | FC St. Pauli | 1:1 (0:1) | ||
| 13:30 | Dynamo Dresden | - | Holstein Kiel | 0:0 (0:0) | ||
| 20:30 | Hamburger SV | - | Karlsruher SC | 3:0 (2:0) | ||
| 17.04.2022 | 13:30 | Werder Bremen | - | 1. FC Nürnberg | 1:1 (0:1) | |
| 13:30 | SV Darmstadt 98 | - | FC Schalke 04 | 2:5 (2:3) | ||
| 13:30 | 1. FC Heidenheim 1846 | - | Erzgebirge Aue | 0:2 (0:0) | ||
| 13:30 | Hansa Rostock | - | Jahn Regensburg | 1:1 (1:0) | ||
| 13:30 | FC Ingolstadt 04 | - | SC Paderborn 07 | 0:1 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Schalke 04 | 30 | 17 | 5 | 8 | 64:36 | 28 | 56 |
| 2 |
|
Werder Bremen | 30 | 15 | 9 | 6 | 54:39 | 15 | 54 |
| 3 |
|
FC St. Pauli | 30 | 15 | 8 | 7 | 55:40 | 15 | 53 |
| 4 |
|
SV Darmstadt 98 | 30 | 15 | 6 | 9 | 59:43 | 16 | 51 |
| 5 |
|
1. FC Nürnberg | 30 | 14 | 8 | 8 | 45:39 | 6 | 50 |
| 6 |
|
Hamburger SV | 30 | 12 | 12 | 6 | 54:30 | 24 | 48 |
| 7 |
|
1. FC Heidenheim 1846 | 30 | 13 | 6 | 11 | 37:41 | -4 | 45 |
| 8 |
|
SC Paderborn 07 | 30 | 11 | 11 | 8 | 51:41 | 10 | 44 |
| 9 |
|
Jahn Regensburg | 30 | 10 | 9 | 11 | 47:42 | 5 | 39 |
| 10 |
|
Karlsruher SC | 30 | 9 | 12 | 9 | 50:47 | 3 | 39 |
| 11 |
|
Holstein Kiel | 30 | 10 | 8 | 12 | 38:48 | -10 | 38 |
| 12 |
|
Hansa Rostock | 30 | 10 | 8 | 12 | 37:47 | -10 | 38 |
| 13 |
|
Fortuna Düsseldorf | 30 | 9 | 10 | 11 | 38:36 | 2 | 37 |
| 14 |
|
Hannover 96 | 30 | 9 | 9 | 12 | 29:42 | -13 | 36 |
| 15 |
|
SV Sandhausen | 30 | 8 | 11 | 11 | 34:47 | -13 | 35 |
| 16 |
|
Dynamo Dresden | 30 | 7 | 8 | 15 | 28:40 | -12 | 29 |
| 17 |
|
Erzgebirge Aue | 30 | 5 | 7 | 18 | 29:61 | -32 | 22 |
| 18 |
|
FC Ingolstadt 04 | 30 | 4 | 7 | 19 | 26:56 | -30 | 19 |
| Promotie | |
| Promotie en degradatie | |
| Promotie en degradatie | |
| Degradatie |
