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| 29.04.2022 | 18:30 | Werder Bremen | - | Holstein Kiel | 2:3 (2:1) | |
| 18:30 | 1. FC Heidenheim 1846 | - | Fortuna Düsseldorf | 1:3 (0:2) | ||
| 18:30 | FC St. Pauli | - | 1. FC Nürnberg | 1:1 (0:0) | ||
| 18:30 | Hannover 96 | - | Karlsruher SC | 2:0 (1:0) | ||
| 18:30 | SV Sandhausen | - | FC Schalke 04 | 1:2 (0:0) | ||
| 30.04.2022 | 13:30 | Dynamo Dresden | - | Jahn Regensburg | 1:1 (0:0) | |
| 13:30 | Hansa Rostock | - | SC Paderborn 07 | 0:0 (0:0) | ||
| 13:30 | FC Ingolstadt 04 | - | Hamburger SV | 0:4 (0:2) | ||
| 20:30 | SV Darmstadt 98 | - | Erzgebirge Aue | 6:0 (4:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Schalke 04 | 32 | 18 | 5 | 9 | 67:41 | 26 | 59 |
| 2 |
|
SV Darmstadt 98 | 32 | 17 | 6 | 9 | 67:44 | 23 | 57 |
| 3 |
|
Werder Bremen | 32 | 16 | 9 | 7 | 60:43 | 17 | 57 |
| 4 |
|
Hamburger SV | 32 | 14 | 12 | 6 | 62:32 | 30 | 54 |
| 5 |
|
FC St. Pauli | 32 | 15 | 9 | 8 | 57:43 | 14 | 54 |
| 6 |
|
1. FC Nürnberg | 32 | 14 | 9 | 9 | 48:44 | 4 | 51 |
| 7 |
|
SC Paderborn 07 | 32 | 12 | 12 | 8 | 54:41 | 13 | 48 |
| 8 |
|
1. FC Heidenheim 1846 | 32 | 13 | 7 | 12 | 39:45 | -6 | 46 |
| 9 |
|
Holstein Kiel | 32 | 11 | 9 | 12 | 42:51 | -9 | 42 |
| 10 |
|
Fortuna Düsseldorf | 32 | 10 | 11 | 11 | 43:39 | 4 | 41 |
| 11 |
|
Jahn Regensburg | 32 | 10 | 10 | 12 | 50:47 | 3 | 40 |
| 12 |
|
Karlsruher SC | 32 | 9 | 13 | 10 | 52:51 | 1 | 40 |
| 13 |
|
Hansa Rostock | 32 | 10 | 10 | 12 | 39:49 | -10 | 40 |
| 14 |
|
Hannover 96 | 32 | 10 | 9 | 13 | 31:45 | -14 | 39 |
| 15 |
|
SV Sandhausen | 32 | 9 | 11 | 12 | 39:51 | -12 | 38 |
| 16 |
|
Dynamo Dresden | 32 | 7 | 10 | 15 | 31:43 | -12 | 31 |
| 17 |
|
Erzgebirge Aue | 32 | 5 | 8 | 19 | 31:69 | -38 | 23 |
| 18 |
|
FC Ingolstadt 04 | 32 | 4 | 8 | 20 | 28:62 | -34 | 20 |
| Promotie | |
| Promotie en degradatie | |
| Promotie en degradatie | |
| Degradatie |
