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| 14.04.2023 | 18:30 | Hannover 96 | - | 1. FC Heidenheim 1846 | 0:3 (0:3) | |
| 18:30 | SpVgg Greuther Fürth | - | Jahn Regensburg | 2:1 (0:0) | ||
| 15.04.2023 | 13:00 | Holstein Kiel | - | 1. FC Nürnberg | 2:1 (2:0) | |
| 13:00 | SC Paderborn 07 | - | Hansa Rostock | 3:0 (0:0) | ||
| 13:00 | 1. FC Magdeburg | - | SV Sandhausen | 1:2 (0:1) | ||
| 20:30 | 1. FC Kaiserslautern | - | Hamburger SV | 2:0 (0:0) | ||
| 16.04.2023 | 13:30 | Karlsruher SC | - | Arminia Bielefeld | 4:2 (0:1) | |
| 13:30 | Fortuna Düsseldorf | - | SV Darmstadt 98 | 1:0 (0:0) | ||
| 13:30 | FC St. Pauli | - | Eintracht Braunschweig | 1:2 (0:2) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SV Darmstadt 98 | 28 | 17 | 7 | 4 | 43:23 | 20 | 58 |
| 2 |
|
1. FC Heidenheim 1846 | 28 | 15 | 9 | 4 | 56:31 | 25 | 54 |
| 3 |
|
Hamburger SV | 28 | 16 | 5 | 7 | 54:35 | 19 | 53 |
| 4 |
|
Fortuna Düsseldorf | 28 | 14 | 5 | 9 | 48:36 | 12 | 47 |
| 5 |
|
FC St. Pauli | 28 | 13 | 8 | 7 | 42:30 | 12 | 47 |
| 6 |
|
SC Paderborn 07 | 28 | 14 | 4 | 10 | 54:34 | 20 | 46 |
| 7 |
|
1. FC Kaiserslautern (N) | 28 | 11 | 10 | 7 | 43:37 | 6 | 43 |
| 8 |
|
Holstein Kiel | 28 | 10 | 10 | 8 | 48:46 | 2 | 40 |
| 9 |
|
Karlsruher SC | 28 | 11 | 6 | 11 | 47:44 | 3 | 39 |
| 10 |
|
SpVgg Greuther Fürth (A) | 28 | 9 | 9 | 10 | 39:41 | -2 | 36 |
| 11 |
|
Hannover 96 | 28 | 9 | 7 | 12 | 37:43 | -6 | 34 |
| 12 |
|
Eintracht Braunschweig (N) | 28 | 8 | 8 | 12 | 34:45 | -11 | 32 |
| 13 |
|
1. FC Magdeburg (N) | 28 | 9 | 5 | 14 | 37:49 | -12 | 32 |
| 14 |
|
1. FC Nürnberg | 28 | 8 | 6 | 14 | 24:41 | -17 | 30 |
| 15 |
|
Arminia Bielefeld (A) | 28 | 8 | 5 | 15 | 43:49 | -6 | 29 |
| 16 |
|
Jahn Regensburg | 28 | 7 | 6 | 15 | 28:45 | -17 | 27 |
| 17 |
|
Hansa Rostock | 28 | 7 | 4 | 17 | 23:46 | -23 | 25 |
| 18 |
|
SV Sandhausen | 28 | 6 | 6 | 16 | 29:54 | -25 | 24 |
| Promotie | |
| Promotie en degradatie | |
| Promotie en degradatie | |
| Degradatie |
