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| 19.05.2023 | 18:30 | Holstein Kiel | - | FC St. Pauli | 3:4 (1:1) | |
| 18:30 | SV Darmstadt 98 | - | 1. FC Magdeburg | 1:0 (1:0) | ||
| 20.05.2023 | 13:00 | Arminia Bielefeld | - | SC Paderborn 07 | 2:2 (2:1) | |
| 13:00 | 1. FC Heidenheim 1846 | - | SV Sandhausen | 1:0 (0:0) | ||
| 13:00 | Eintracht Braunschweig | - | Jahn Regensburg | 1:2 (1:1) | ||
| 20:30 | Hamburger SV | - | SpVgg Greuther Fürth | 2:1 (1:0) | ||
| 21.05.2023 | 13:30 | Fortuna Düsseldorf | - | Hannover 96 | 3:3 (1:2) | |
| 13:30 | 1. FC Nürnberg | - | Hansa Rostock | 0:0 (0:0) | ||
| 13:30 | Karlsruher SC | - | 1. FC Kaiserslautern | 2:0 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SV Darmstadt 98 | 33 | 20 | 7 | 6 | 50:29 | 21 | 67 |
| 2 |
|
1. FC Heidenheim 1846 | 33 | 18 | 10 | 5 | 64:34 | 30 | 64 |
| 3 |
|
Hamburger SV | 33 | 19 | 6 | 8 | 69:45 | 24 | 63 |
| 4 |
|
FC St. Pauli | 33 | 16 | 9 | 8 | 54:38 | 16 | 57 |
| 5 |
|
SC Paderborn 07 | 33 | 16 | 7 | 10 | 68:43 | 25 | 55 |
| 6 |
|
Fortuna Düsseldorf | 33 | 16 | 7 | 10 | 57:43 | 14 | 55 |
| 7 |
|
Karlsruher SC | 33 | 13 | 6 | 14 | 55:52 | 3 | 45 |
| 8 |
|
1. FC Kaiserslautern (N) | 33 | 11 | 12 | 10 | 47:45 | 2 | 45 |
| 9 |
|
Hannover 96 | 33 | 12 | 8 | 13 | 49:50 | -1 | 44 |
| 10 |
|
Holstein Kiel | 33 | 11 | 10 | 12 | 53:60 | -7 | 43 |
| 11 |
|
1. FC Magdeburg (N) | 33 | 11 | 7 | 15 | 44:55 | -11 | 40 |
| 12 |
|
SpVgg Greuther Fürth (A) | 33 | 9 | 11 | 13 | 43:50 | -7 | 38 |
| 13 |
|
Hansa Rostock | 33 | 11 | 5 | 17 | 30:47 | -17 | 38 |
| 14 |
|
Eintracht Braunschweig (N) | 33 | 9 | 9 | 15 | 41:57 | -16 | 36 |
| 15 |
|
1. FC Nürnberg | 33 | 9 | 9 | 15 | 31:49 | -18 | 36 |
| 16 |
|
Arminia Bielefeld (A) | 33 | 9 | 7 | 17 | 50:58 | -8 | 34 |
| 17 |
|
Jahn Regensburg | 33 | 8 | 7 | 18 | 32:55 | -23 | 31 |
| 18 |
|
SV Sandhausen | 33 | 7 | 7 | 19 | 35:62 | -27 | 28 |
| Promotie | |
| Promotie en degradatie | |
| Promotie en degradatie | |
| Degradatie |
