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| 18.04.2022 | 14:00 | Estudiantes II | - | Tigre II | 2:1 (0:0) | |
| 14:00 | Boca Juniors II | - | Godoy Cruz II | 6:0 (4:0) | ||
| 15:00 | Huracán II | - | Colón de Santa Fe II | 1:3 (1:0) | ||
| 15:00 | Arsenal de Sarandí II | - | Barracas Central II | 0:0 (0:0) | ||
| 19.04.2022 | 14:00 | Lanús II | - | Rosario Central II | 1:0 (0:0) | |
| 14:00 | Independiente II | - | Aldosivi II | 1:2 (0:1) | ||
| 16:00 | Newell's Old Boys II | - | Banfield II | 1:0 (1:0) | ||
| 16:00 | Vélez Sarsfield II | - | Central Córdoba SdE II | 1:0 (1:0) | ||
| 20.04.2022 | 14:00 | Platense II | - | Gimnasia de La Plata II | 1:0 (0:0) | |
| 15:00 | Patronato de Paraná II | - | Racing Club II | 3:1 (2:0) | ||
| 15:00 | Unión de Santa Fe II | - | San Lorenzo II | 1:4 (0:0) | ||
| 16:00 | Sarmiento de Junín II | - | Defensa y Justicia II | 0:1 (0:0) | ||
| 16:00 | Talleres de Córdoba II | - | River Plate II | 1:1 (0:1) | ||
| 21.04.2022 | 16:00 | Atlético Tucumán II | - | Argentinos Juniors II | 2:1 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Defensa y Justicia II | 11 | 9 | 0 | 2 | 17:7 | 10 | 27 |
| 2 |
|
Banfield II | 11 | 7 | 2 | 2 | 18:11 | 7 | 23 |
| 3 |
|
Gimnasia de La Plata II | 11 | 7 | 0 | 4 | 21:16 | 5 | 21 |
| 4 |
|
River Plate II | 11 | 5 | 4 | 2 | 17:12 | 5 | 19 |
| 5 |
|
Atlético Tucumán II | 11 | 5 | 2 | 4 | 21:20 | 1 | 17 |
| 6 |
|
Argentinos Juniors II | 11 | 4 | 3 | 4 | 17:9 | 8 | 15 |
| 7 |
|
Newell's Old Boys II | 11 | 4 | 3 | 4 | 15:14 | 1 | 15 |
| 8 |
|
Platense II | 11 | 4 | 3 | 4 | 14:15 | -1 | 15 |
| 9 |
|
Sarmiento de Junín II | 11 | 4 | 2 | 5 | 12:11 | 1 | 14 |
| 10 |
|
Talleres de Córdoba II | 11 | 3 | 4 | 4 | 23:18 | 5 | 13 |
| 11 |
|
San Lorenzo II | 11 | 3 | 3 | 5 | 13:20 | -7 | 12 |
| 12 |
|
Unión de Santa Fe II | 11 | 2 | 4 | 5 | 6:20 | -14 | 10 |
| 13 |
|
Patronato de Paraná II | 11 | 2 | 2 | 7 | 9:15 | -6 | 8 |
| 14 |
|
Racing Club II | 11 | 2 | 1 | 8 | 14:23 | -9 | 7 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Central Córdoba SdE II | 11 | 6 | 3 | 2 | 15:8 | 7 | 21 |
| 2 |
|
Lanús II | 11 | 6 | 3 | 2 | 18:13 | 5 | 21 |
| 3 |
|
Aldosivi II | 11 | 6 | 1 | 4 | 16:11 | 5 | 19 |
| 4 |
|
Tigre II | 11 | 5 | 3 | 3 | 18:12 | 6 | 18 |
| 5 |
|
Estudiantes II | 11 | 5 | 3 | 3 | 18:16 | 2 | 18 |
| 6 |
|
Rosario Central II | 11 | 5 | 2 | 4 | 19:11 | 8 | 17 |
| 7 |
|
Boca Juniors II | 11 | 4 | 5 | 2 | 18:11 | 7 | 17 |
| 8 |
|
Arsenal de Sarandí II | 11 | 4 | 3 | 4 | 10:13 | -3 | 15 |
| 9 |
|
Huracán II | 11 | 4 | 2 | 5 | 19:13 | 6 | 14 |
| 10 |
|
Independiente II | 11 | 3 | 4 | 4 | 12:12 | 0 | 13 |
| 11 |
|
Colón de Santa Fe II | 11 | 4 | 1 | 6 | 10:13 | -3 | 13 |
| 12 |
|
Vélez Sarsfield II | 11 | 3 | 3 | 5 | 15:18 | -3 | 12 |
| 13 |
|
Barracas Central II | 11 | 3 | 2 | 6 | 12:25 | -13 | 11 |
| 14 |
|
Godoy Cruz II | 11 | 1 | 0 | 10 | 5:35 | -30 | 3 |
| Play-offs | |
| Play-offs |
