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| 23.04.2022 | 16:00 | Central Córdoba SdE II | - | Boca Juniors II | 0:0 (0:0) | |
| 24.04.2022 | 14:00 | San Lorenzo II | - | Patronato de Paraná II | 3:0 (2:0) | |
| 15:00 | Godoy Cruz II | - | Lanús II | 0:1 (0:0) | ||
| 15:00 | Barracas Central II | - | Vélez Sarsfield II | 0:0 (0:0) | ||
| 25.04.2022 | 14:00 | River Plate II | - | Atlético Tucumán II | 4:0 (2:0) | |
| 16:00 | Argentinos Juniors II | - | Sarmiento de Junín II | 0:0 (0:0) | ||
| 16:00 | Defensa y Justicia II | - | Platense II | 1:1 (1:1) | ||
| 16:00 | Gimnasia de La Plata II | - | Unión de Santa Fe II | 1:2 (0:2) | ||
| 16:00 | Tigre II | - | Arsenal de Sarandí II | 1:1 (1:0) | ||
| 16:00 | Colón de Santa Fe II | - | Estudiantes II | 0:3 (0:2) | ||
| 16:00 | Aldosivi II | - | Huracán II | 1:2 (0:1) | ||
| 16:00 | Rosario Central II | - | Independiente II | 1:2 (0:0) | ||
| 26.04.2022 | 14:00 | Racing Club II | - | Newell's Old Boys II | 1:1 (1:0) | |
| 16:00 | Banfield II | - | Talleres de Córdoba II | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Defensa y Justicia II | 12 | 9 | 1 | 2 | 18:8 | 10 | 28 |
| 2 |
|
Banfield II | 12 | 7 | 3 | 2 | 18:11 | 7 | 24 |
| 3 |
|
River Plate II | 12 | 6 | 4 | 2 | 21:12 | 9 | 22 |
| 4 |
|
Gimnasia de La Plata II | 12 | 7 | 0 | 5 | 22:18 | 4 | 21 |
| 5 |
|
Atlético Tucumán II | 12 | 5 | 2 | 5 | 21:24 | -3 | 17 |
| 6 |
|
Argentinos Juniors II | 12 | 4 | 4 | 4 | 17:9 | 8 | 16 |
| 7 |
|
Newell's Old Boys II | 12 | 4 | 4 | 4 | 16:15 | 1 | 16 |
| 8 |
|
Platense II | 12 | 4 | 4 | 4 | 15:16 | -1 | 16 |
| 9 |
|
Sarmiento de Junín II | 12 | 4 | 3 | 5 | 12:11 | 1 | 15 |
| 10 |
|
San Lorenzo II | 12 | 4 | 3 | 5 | 16:20 | -4 | 15 |
| 11 |
|
Talleres de Córdoba II | 12 | 3 | 5 | 4 | 23:18 | 5 | 14 |
| 12 |
|
Unión de Santa Fe II | 12 | 3 | 4 | 5 | 8:21 | -13 | 13 |
| 13 |
|
Racing Club II | 12 | 2 | 2 | 8 | 15:24 | -9 | 8 |
| 14 |
|
Patronato de Paraná II | 12 | 2 | 2 | 8 | 9:18 | -9 | 8 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Lanús II | 12 | 7 | 3 | 2 | 19:13 | 6 | 24 |
| 2 |
|
Central Córdoba SdE II | 12 | 6 | 4 | 2 | 15:8 | 7 | 22 |
| 3 |
|
Estudiantes II | 12 | 6 | 3 | 3 | 21:16 | 5 | 21 |
| 4 |
|
Tigre II | 12 | 5 | 4 | 3 | 19:13 | 6 | 19 |
| 5 |
|
Aldosivi II | 12 | 6 | 1 | 5 | 17:13 | 4 | 19 |
| 6 |
|
Boca Juniors II | 12 | 4 | 6 | 2 | 18:11 | 7 | 18 |
| 7 |
|
Huracán II | 12 | 5 | 2 | 5 | 21:14 | 7 | 17 |
| 8 |
|
Rosario Central II | 12 | 5 | 2 | 5 | 20:13 | 7 | 17 |
| 9 |
|
Independiente II | 12 | 4 | 4 | 4 | 14:13 | 1 | 16 |
| 10 |
|
Arsenal de Sarandí II | 12 | 4 | 4 | 4 | 11:14 | -3 | 16 |
| 11 |
|
Vélez Sarsfield II | 12 | 3 | 4 | 5 | 15:18 | -3 | 13 |
| 12 |
|
Colón de Santa Fe II | 12 | 4 | 1 | 7 | 10:16 | -6 | 13 |
| 13 |
|
Barracas Central II | 12 | 3 | 3 | 6 | 12:25 | -13 | 12 |
| 14 |
|
Godoy Cruz II | 12 | 1 | 0 | 11 | 5:36 | -31 | 3 |
| Play-offs | |
| Play-offs |
