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| 05.05.2022 | 14:00 | River Plate II | - | Platense II | 2:2 (1:0) | |
| 14:00 | Rosario Central II | - | Estudiantes II | 0:1 (0:0) | ||
| 16:00 | Argentinos Juniors II | - | Unión de Santa Fe II | 4:0 (1:0) | ||
| 16:00 | Gimnasia de La Plata II | - | Newell's Old Boys II | 1:3 (1:3) | ||
| 06.05.2022 | 14:00 | Central Córdoba SdE II | - | Lanús II | 2:2 (2:2) | |
| 14:00 | Tigre II | - | Boca Juniors II | 1:0 (0:0) | ||
| 14:00 | Aldosivi II | - | Arsenal de Sarandí II | 1:1 (1:0) | ||
| 14:00 | Independiente II | - | Huracán II | 0:4 (0:1) | ||
| 15:00 | Banfield II | - | Atlético Tucumán II | 3:4 (1:2) | ||
| 15:00 | Talleres de Córdoba II | - | Sarmiento de Junín II | 2:0 (0:0) | ||
| 15:00 | Defensa y Justicia II | - | Patronato de Paraná II | 3:0 (2:0) | ||
| 15:00 | Colón de Santa Fe II | - | Vélez Sarsfield II | 1:0 (0:0) | ||
| 09.05.2022 | 14:00 | San Lorenzo II | - | Racing Club II | 3:1 (3:1) | |
| 16:00 | Barracas Central II | - | Godoy Cruz II | 0:2 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Defensa y Justicia II | 14 | 10 | 1 | 3 | 21:10 | 11 | 31 |
| 2 |
|
River Plate II | 14 | 7 | 5 | 2 | 25:15 | 10 | 26 |
| 3 |
|
Banfield II | 14 | 7 | 3 | 4 | 21:17 | 4 | 24 |
| 4 |
|
Gimnasia de La Plata II | 14 | 7 | 1 | 6 | 25:23 | 2 | 22 |
| 5 |
|
San Lorenzo II | 14 | 6 | 3 | 5 | 22:21 | 1 | 21 |
| 6 |
|
Argentinos Juniors II | 14 | 5 | 5 | 4 | 22:10 | 12 | 20 |
| 7 |
|
Talleres de Córdoba II | 14 | 5 | 5 | 4 | 27:18 | 9 | 20 |
| 8 |
|
Atlético Tucumán II | 14 | 6 | 2 | 6 | 25:29 | -4 | 20 |
| 9 |
|
Newell's Old Boys II | 14 | 5 | 4 | 5 | 19:19 | 0 | 19 |
| 10 |
|
Platense II | 14 | 4 | 6 | 4 | 18:19 | -1 | 18 |
| 11 |
|
Unión de Santa Fe II | 14 | 4 | 4 | 6 | 10:25 | -15 | 16 |
| 12 |
|
Sarmiento de Junín II | 14 | 4 | 3 | 7 | 13:15 | -2 | 15 |
| 13 |
|
Racing Club II | 14 | 3 | 2 | 9 | 18:27 | -9 | 11 |
| 14 |
|
Patronato de Paraná II | 14 | 2 | 3 | 9 | 11:23 | -12 | 9 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Estudiantes II | 14 | 8 | 3 | 3 | 25:17 | 8 | 27 |
| 2 |
|
Lanús II | 14 | 7 | 4 | 3 | 22:17 | 5 | 25 |
| 3 |
|
Huracán II | 14 | 7 | 2 | 5 | 28:14 | 14 | 23 |
| 4 |
|
Central Córdoba SdE II | 14 | 6 | 5 | 3 | 17:11 | 6 | 23 |
| 5 |
|
Tigre II | 14 | 6 | 4 | 4 | 22:17 | 5 | 22 |
| 6 |
|
Boca Juniors II | 14 | 5 | 6 | 3 | 20:12 | 8 | 21 |
| 7 |
|
Aldosivi II | 14 | 6 | 2 | 6 | 19:17 | 2 | 20 |
| 8 |
|
Arsenal de Sarandí II | 14 | 5 | 5 | 4 | 13:15 | -2 | 20 |
| 9 |
|
Independiente II | 14 | 5 | 4 | 5 | 16:18 | -2 | 19 |
| 10 |
|
Rosario Central II | 14 | 5 | 2 | 7 | 20:17 | 3 | 17 |
| 11 |
|
Vélez Sarsfield II | 14 | 4 | 4 | 6 | 19:21 | -2 | 16 |
| 12 |
|
Colón de Santa Fe II | 14 | 5 | 1 | 8 | 11:17 | -6 | 16 |
| 13 |
|
Barracas Central II | 14 | 3 | 3 | 8 | 12:29 | -17 | 12 |
| 14 |
|
Godoy Cruz II | 14 | 3 | 0 | 11 | 8:36 | -28 | 9 |
| Play-offs | |
| Play-offs |
