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| 24.02.2022 | 13:00 | Talleres de Córdoba II | - | Newell's Old Boys II | 2:2 (0:1) | |
| 13:00 | River Plate II | - | Racing Club II | 4:2 (1:1) | ||
| 13:00 | Huracán II | - | Vélez Sarsfield II | 2:3 (1:1) | ||
| 25.02.2022 | 13:00 | Sarmiento de Junín II | - | Unión de Santa Fe II | 2:0 (1:0) | |
| 13:00 | Atlético Tucumán II | - | Patronato de Paraná II | 4:1 (1:1) | ||
| 13:00 | Lanús II | - | Tigre II | 1:1 (0:1) | ||
| 13:00 | Colón de Santa Fe II | - | Barracas Central II | 3:2 (1:1) | ||
| 13:00 | Independiente II | - | Boca Juniors II | 1:1 (0:0) | ||
| 13:00 | Estudiantes II | - | Arsenal de Sarandí II | 1:0 (1:0) | ||
| 26.02.2022 | 13:00 | Argentinos Juniors II | - | San Lorenzo II | 2:0 (1:0) | |
| 13:00 | Defensa y Justicia II | - | Gimnasia de La Plata II | 2:1 (1:0) | ||
| 13:00 | Aldosivi II | - | Central Córdoba SdE II | 0:1 (0:0) | ||
| 13:00 | Rosario Central II | - | Godoy Cruz II | 5:1 (3:0) | ||
| 27.02.2022 | 13:00 | Platense II | - | Banfield II | 1:2 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Banfield II | 4 | 4 | 0 | 0 | 9:5 | 4 | 12 |
| 2 |
|
Argentinos Juniors II | 4 | 3 | 1 | 0 | 8:1 | 7 | 10 |
| 3 |
|
River Plate II | 4 | 3 | 1 | 0 | 7:3 | 4 | 10 |
| 4 |
|
Defensa y Justicia II | 4 | 3 | 0 | 1 | 7:3 | 4 | 9 |
| 5 |
|
Sarmiento de Junín II | 4 | 2 | 1 | 1 | 5:3 | 2 | 7 |
| 6 |
|
Talleres de Córdoba II | 4 | 1 | 3 | 0 | 9:4 | 5 | 6 |
| 7 |
|
Atlético Tucumán II | 4 | 2 | 0 | 2 | 8:5 | 3 | 6 |
| 8 |
|
Gimnasia de La Plata II | 4 | 2 | 0 | 2 | 9:8 | 1 | 6 |
| 9 |
|
Newell's Old Boys II | 4 | 1 | 2 | 1 | 6:5 | 1 | 5 |
| 10 |
|
Unión de Santa Fe II | 4 | 1 | 1 | 2 | 1:7 | -6 | 4 |
| 11 |
|
Platense II | 4 | 0 | 2 | 2 | 4:7 | -3 | 2 |
| 12 |
|
Patronato de Paraná II | 4 | 0 | 1 | 3 | 2:7 | -5 | 1 |
| 13 |
|
San Lorenzo II | 4 | 0 | 0 | 4 | 2:10 | -8 | 0 |
| 14 |
|
Racing Club II | 4 | 0 | 0 | 4 | 3:12 | -9 | 0 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Central Córdoba SdE II | 4 | 3 | 1 | 0 | 9:2 | 7 | 10 |
| 2 |
|
Tigre II | 4 | 2 | 2 | 0 | 8:2 | 6 | 8 |
| 3 |
|
Vélez Sarsfield II | 4 | 2 | 2 | 0 | 7:5 | 2 | 8 |
| 4 |
|
Arsenal de Sarandí II | 4 | 2 | 1 | 1 | 5:4 | 1 | 7 |
| 5 |
|
Estudiantes II | 4 | 2 | 1 | 1 | 8:8 | 0 | 7 |
| 6 |
|
Colón de Santa Fe II | 4 | 2 | 1 | 1 | 5:5 | 0 | 7 |
| 7 |
|
Aldosivi II | 4 | 2 | 0 | 2 | 8:6 | 2 | 6 |
| 8 |
|
Rosario Central II | 4 | 1 | 2 | 1 | 7:4 | 3 | 5 |
| 9 |
|
Independiente II | 4 | 0 | 4 | 0 | 5:5 | 0 | 4 |
| 10 |
|
Lanús II | 4 | 1 | 1 | 2 | 6:7 | -1 | 4 |
| 11 |
|
Boca Juniors II | 4 | 0 | 3 | 1 | 3:4 | -1 | 3 |
| 12 |
|
Huracán II | 4 | 1 | 0 | 3 | 5:7 | -2 | 3 |
| 13 |
|
Barracas Central II | 4 | 1 | 0 | 3 | 5:12 | -7 | 3 |
| 14 |
|
Godoy Cruz II | 4 | 0 | 0 | 4 | 2:12 | -10 | 0 |
| Play-offs | |
| Play-offs |
