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| 07.04.2022 | 14:00 | Lanús II | - | Aldosivi II | 2:1 (2:1) | |
| 14:00 | Independiente II | - | Tigre II | 0:1 (0:0) | ||
| 15:00 | Arsenal de Sarandí II | - | Godoy Cruz II | 1:0 (1:0) | ||
| 16:00 | Rosario Central II | - | Colón de Santa Fe II | 3:1 (2:0) | ||
| 08.04.2022 | 14:00 | Platense II | - | Racing Club II | 1:0 (0:0) | |
| 14:00 | Vélez Sarsfield II | - | Boca Juniors II | 2:3 (1:2) | ||
| 15:00 | Patronato de Paraná II | - | Banfield II | 0:2 (0:2) | ||
| 15:00 | Unión de Santa Fe II | - | Newell's Old Boys II | 1:1 (0:1) | ||
| 15:00 | Huracán II | - | Barracas Central II | 5:0 (2:0) | ||
| 16:00 | Talleres de Córdoba II | - | Defensa y Justicia II | 1:2 (0:2) | ||
| 16:00 | Estudiantes II | - | Central Córdoba SdE II | 0:0 (0:0) | ||
| 09.04.2022 | 15:00 | River Plate II | - | Argentinos Juniors II | 0:0 (0:0) | |
| 10.04.2022 | 16:00 | Sarmiento de Junín II | - | San Lorenzo II | 1:2 (0:1) | |
| 11.04.2022 | 15:00 | Atlético Tucumán II | - | Gimnasia de La Plata II | 3:2 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Banfield II | 9 | 7 | 2 | 0 | 16:7 | 9 | 23 |
| 2 |
|
Defensa y Justicia II | 9 | 7 | 0 | 2 | 15:7 | 8 | 21 |
| 3 |
|
Gimnasia de La Plata II | 9 | 6 | 0 | 3 | 20:15 | 5 | 18 |
| 4 |
|
River Plate II | 9 | 4 | 3 | 2 | 13:9 | 4 | 15 |
| 5 |
|
Sarmiento de Junín II | 9 | 4 | 2 | 3 | 12:9 | 3 | 14 |
| 6 |
|
Atlético Tucumán II | 9 | 4 | 2 | 3 | 19:18 | 1 | 14 |
| 7 |
|
Talleres de Córdoba II | 9 | 3 | 3 | 3 | 22:12 | 10 | 12 |
| 8 |
|
Argentinos Juniors II | 9 | 3 | 3 | 3 | 11:7 | 4 | 12 |
| 9 |
|
Platense II | 9 | 3 | 2 | 4 | 12:14 | -2 | 11 |
| 10 |
|
Unión de Santa Fe II | 9 | 2 | 4 | 3 | 5:14 | -9 | 10 |
| 11 |
|
Newell's Old Boys II | 9 | 2 | 3 | 4 | 13:14 | -1 | 9 |
| 12 |
|
San Lorenzo II | 9 | 2 | 2 | 5 | 8:18 | -10 | 8 |
| 13 |
|
Patronato de Paraná II | 9 | 1 | 2 | 6 | 6:13 | -7 | 5 |
| 14 |
|
Racing Club II | 9 | 1 | 1 | 7 | 11:20 | -9 | 4 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Tigre II | 9 | 5 | 3 | 1 | 16:7 | 9 | 18 |
| 2 |
|
Central Córdoba SdE II | 9 | 5 | 3 | 1 | 13:7 | 6 | 18 |
| 3 |
|
Rosario Central II | 9 | 5 | 2 | 2 | 19:9 | 10 | 17 |
| 4 |
|
Lanús II | 9 | 4 | 3 | 2 | 14:12 | 2 | 15 |
| 5 |
|
Boca Juniors II | 9 | 3 | 5 | 1 | 11:8 | 3 | 14 |
| 6 |
|
Estudiantes II | 9 | 4 | 2 | 3 | 14:13 | 1 | 14 |
| 7 |
|
Arsenal de Sarandí II | 9 | 4 | 2 | 3 | 10:11 | -1 | 14 |
| 8 |
|
Aldosivi II | 9 | 4 | 1 | 4 | 13:10 | 3 | 13 |
| 9 |
|
Huracán II | 9 | 3 | 2 | 4 | 15:9 | 6 | 11 |
| 10 |
|
Independiente II | 9 | 2 | 4 | 3 | 10:10 | 0 | 10 |
| 11 |
|
Colón de Santa Fe II | 9 | 3 | 1 | 5 | 7:11 | -4 | 10 |
| 12 |
|
Vélez Sarsfield II | 9 | 2 | 3 | 4 | 14:17 | -3 | 9 |
| 13 |
|
Barracas Central II | 9 | 3 | 0 | 6 | 10:23 | -13 | 9 |
| 14 |
|
Godoy Cruz II | 9 | 0 | 0 | 9 | 4:29 | -25 | 0 |
| Play-offs | |
| Play-offs |
