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| 23.04.2022 | 01:30 | Colón de Santa Fe | - | Estudiantes | 2:2 (2:1) | |
| 19:00 | Gimnasia de La Plata | - | Unión de Santa Fe | 1:0 (0:0) | ||
| 19:00 | San Lorenzo | - | Patronato de Paraná | 1:2 (0:1) | ||
| 21:30 | Rosario Central | - | Independiente | 3:0 (1:0) | ||
| 24.04.2022 | 00:00 | Central Córdoba SdE | - | Boca Juniors | 1:2 (1:1) | |
| 02:30 | Banfield | - | Talleres de Córdoba | 3:1 (1:0) | ||
| 02:30 | Barracas Central | - | Vélez Sarsfield | 1:1 (1:0) | ||
| 21:30 | Racing Club | - | Newell's Old Boys | 0:0 (0:0) | ||
| 25.04.2022 | 00:00 | River Plate | - | Atlético Tucumán | 1:1 (1:0) | |
| 02:30 | Defensa y Justicia | - | Platense | 1:1 (0:0) | ||
| 02:30 | Godoy Cruz | - | Lanús | 1:1 (1:1) | ||
| 20:30 | Tigre | - | Arsenal de Sarandí | 0:0 (0:0) | ||
| 26.04.2022 | 02:30 | Argentinos Juniors | - | Sarmiento de Junín | 0:0 (0:0) | |
| 02:30 | Aldosivi | - | Huracán | 0:2 (0:2) |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing Club | 12 | 8 | 4 | 0 | 23:8 | 15 | 28 |
| 2 |
|
River Plate | 12 | 7 | 2 | 3 | 22:11 | 11 | 23 |
| 3 |
|
Newell's Old Boys | 12 | 7 | 2 | 3 | 15:10 | 5 | 23 |
| 4 |
|
Argentinos Juniors | 12 | 6 | 3 | 3 | 18:14 | 4 | 21 |
| 5 |
|
Sarmiento de Junín | 12 | 6 | 3 | 3 | 17:16 | 1 | 21 |
| 6 |
|
Defensa y Justicia | 12 | 5 | 4 | 3 | 23:18 | 5 | 19 |
| 7 |
|
Gimnasia de La Plata | 12 | 5 | 3 | 4 | 15:19 | -4 | 18 |
| 8 |
|
Banfield | 12 | 5 | 2 | 5 | 16:13 | 3 | 17 |
| 9 |
|
Unión de Santa Fe | 12 | 5 | 2 | 5 | 9:9 | 0 | 17 |
| 10 |
|
San Lorenzo | 12 | 2 | 5 | 5 | 12:15 | -3 | 11 |
| 11 |
|
Patronato de Paraná | 12 | 3 | 1 | 8 | 10:18 | -8 | 10 |
| 12 |
|
Platense | 12 | 2 | 3 | 7 | 10:20 | -10 | 9 |
| 13 |
|
Talleres de Córdoba | 12 | 2 | 2 | 8 | 8:18 | -10 | 8 |
| 14 |
|
Atlético Tucumán | 12 | 1 | 4 | 7 | 9:22 | -13 | 7 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Estudiantes | 12 | 7 | 4 | 1 | 30:16 | 14 | 25 |
| 2 |
|
Boca Juniors | 12 | 5 | 6 | 1 | 15:11 | 4 | 21 |
| 3 |
|
Tigre | 12 | 5 | 5 | 2 | 15:7 | 8 | 20 |
| 4 |
|
Aldosivi | 12 | 6 | 2 | 4 | 15:12 | 3 | 20 |
| 5 |
|
Colón de Santa Fe | 12 | 3 | 7 | 2 | 17:15 | 2 | 16 |
| 6 |
|
Barracas Central | 12 | 5 | 1 | 6 | 14:21 | -7 | 16 |
| 7 |
|
Huracán | 12 | 4 | 3 | 5 | 15:15 | 0 | 15 |
| 8 |
|
Central Córdoba SdE | 12 | 3 | 5 | 4 | 14:19 | -5 | 14 |
| 9 |
|
Godoy Cruz | 12 | 2 | 7 | 3 | 19:21 | -2 | 13 |
| 10 |
|
Independiente | 12 | 2 | 7 | 3 | 14:17 | -3 | 13 |
| 11 |
|
Vélez Sarsfield | 12 | 2 | 6 | 4 | 8:9 | -1 | 12 |
| 12 |
|
Arsenal de Sarandí | 12 | 1 | 8 | 3 | 16:18 | -2 | 11 |
| 13 |
|
Lanús | 12 | 2 | 5 | 5 | 13:15 | -2 | 11 |
| 14 |
|
Rosario Central | 12 | 3 | 2 | 7 | 12:17 | -5 | 11 |
| Play-offs | |
| Play-offs |
