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| 28.04.2022 | 01:30 | Newell's Old Boys | - | San Lorenzo | 1:2 (0:1) | |
| 30.04.2022 | 00:00 | Estudiantes | - | Aldosivi | 2:1 (1:0) | |
| 02:30 | Patronato de Paraná | - | Gimnasia de La Plata | 0:6 (0:3) | ||
| 17:00 | Atlético Tucumán | - | Talleres de Córdoba | 3:0 (2:0) | ||
| 21:00 | Racing Club | - | Banfield | 1:1 (0:0) | ||
| 21:00 | Vélez Sarsfield | - | Tigre | 3:2 (3:1) | ||
| 01.05.2022 | 00:00 | Arsenal de Sarandí | - | Colón de Santa Fe | 2:0 (0:0) | |
| 00:00 | Boca Juniors | - | Barracas Central | 2:0 (1:0) | ||
| 02:30 | Sarmiento de Junín | - | River Plate | 0:7 (0:3) | ||
| 02:30 | Lanús | - | Independiente | 1:0 (0:0) | ||
| 03.05.2022 | 00:00 | Unión de Santa Fe | - | Defensa y Justicia | 1:2 (0:1) | |
| 00:00 | Godoy Cruz | - | Central Córdoba SdE | 1:0 (1:0) | ||
| 02:30 | Platense | - | Argentinos Juniors | 1:1 (0:1) | ||
| 02:30 | Huracán | - | Rosario Central | 2:1 (0:1) |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing Club | 13 | 8 | 5 | 0 | 24:9 | 15 | 29 |
| 2 |
|
River Plate | 13 | 8 | 2 | 3 | 29:11 | 18 | 26 |
| 3 |
|
Newell's Old Boys | 13 | 7 | 2 | 4 | 16:12 | 4 | 23 |
| 4 |
|
Defensa y Justicia | 13 | 6 | 4 | 3 | 25:19 | 6 | 22 |
| 5 |
|
Argentinos Juniors | 13 | 6 | 4 | 3 | 19:15 | 4 | 22 |
| 6 |
|
Gimnasia de La Plata | 13 | 6 | 3 | 4 | 21:19 | 2 | 21 |
| 7 |
|
Sarmiento de Junín | 13 | 6 | 3 | 4 | 17:23 | -6 | 21 |
| 8 |
|
Banfield | 13 | 5 | 3 | 5 | 17:14 | 3 | 18 |
| 9 |
|
Unión de Santa Fe | 13 | 5 | 2 | 6 | 10:11 | -1 | 17 |
| 10 |
|
San Lorenzo | 13 | 3 | 5 | 5 | 14:16 | -2 | 14 |
| 11 |
|
Atlético Tucumán | 13 | 2 | 4 | 7 | 12:22 | -10 | 10 |
| 12 |
|
Platense | 13 | 2 | 4 | 7 | 11:21 | -10 | 10 |
| 13 |
|
Patronato de Paraná | 13 | 3 | 1 | 9 | 10:24 | -14 | 10 |
| 14 |
|
Talleres de Córdoba | 13 | 2 | 2 | 9 | 8:21 | -13 | 8 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Estudiantes | 13 | 8 | 4 | 1 | 32:17 | 15 | 28 |
| 2 |
|
Boca Juniors | 13 | 6 | 6 | 1 | 17:11 | 6 | 24 |
| 3 |
|
Tigre | 13 | 5 | 5 | 3 | 17:10 | 7 | 20 |
| 4 |
|
Aldosivi | 13 | 6 | 2 | 5 | 16:14 | 2 | 20 |
| 5 |
|
Huracán | 13 | 5 | 3 | 5 | 17:16 | 1 | 18 |
| 6 |
|
Colón de Santa Fe | 13 | 3 | 7 | 3 | 17:17 | 0 | 16 |
| 7 |
|
Godoy Cruz | 13 | 3 | 7 | 3 | 20:21 | -1 | 16 |
| 8 |
|
Barracas Central | 13 | 5 | 1 | 7 | 14:23 | -9 | 16 |
| 9 |
|
Vélez Sarsfield | 13 | 3 | 6 | 4 | 11:11 | 0 | 15 |
| 10 |
|
Arsenal de Sarandí | 13 | 2 | 8 | 3 | 18:18 | 0 | 14 |
| 11 |
|
Lanús | 13 | 3 | 5 | 5 | 14:15 | -1 | 14 |
| 12 |
|
Central Córdoba SdE | 13 | 3 | 5 | 5 | 14:20 | -6 | 14 |
| 13 |
|
Independiente | 13 | 2 | 7 | 4 | 14:18 | -4 | 13 |
| 14 |
|
Rosario Central | 13 | 3 | 2 | 8 | 13:19 | -6 | 11 |
| Play-offs | |
| Play-offs |
