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| 25.02.2022 | 01:30 | Huracán | - | Vélez Sarsfield | 2:0 (2:0) | |
| 23:15 | Defensa y Justicia | - | Gimnasia de La Plata | 3:2 (2:1) | ||
| 26.02.2022 | 01:30 | Platense | - | Banfield | 0:1 (0:1) | |
| 21:00 | Colón de Santa Fe | - | Barracas Central | 2:1 (1:1) | ||
| 21:00 | Rosario Central | - | Godoy Cruz | 1:2 (0:0) | ||
| 23:15 | Aldosivi | - | Central Córdoba SdE | 0:0 (0:0) | ||
| 27.02.2022 | 01:30 | Independiente | - | Boca Juniors | 2:2 (1:2) | |
| 21:00 | Sarmiento de Junín | - | Unión de Santa Fe | 2:1 (2:1) | ||
| 21:00 | Estudiantes | - | Arsenal de Sarandí | 3:2 (0:0) | ||
| 23:15 | River Plate | - | Racing Club | 2:2 (2:0) | ||
| 28.02.2022 | 01:30 | Argentinos Juniors | - | San Lorenzo | 1:1 (1:0) | |
| 23:15 | Talleres de Córdoba | - | Newell's Old Boys | 1:2 (0:0) | ||
| 01.03.2022 | 01:30 | Lanús | - | Tigre | 0:0 (0:0) | |
| 02.03.2022 | 01:30 | Atlético Tucumán | - | Patronato de Paraná | 1:0 (0:0) |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Banfield | 4 | 2 | 2 | 0 | 7:2 | 5 | 8 |
| 2 |
|
River Plate | 4 | 2 | 1 | 1 | 8:4 | 4 | 7 |
| 3 |
|
Platense | 4 | 2 | 1 | 1 | 5:3 | 2 | 7 |
| 4 |
|
Defensa y Justicia | 4 | 2 | 1 | 1 | 9:8 | 1 | 7 |
| 5 |
|
Argentinos Juniors | 4 | 2 | 1 | 1 | 5:4 | 1 | 7 |
| 6 |
|
Unión de Santa Fe | 4 | 2 | 1 | 1 | 3:2 | 1 | 7 |
| 7 |
|
Sarmiento de Junín | 4 | 2 | 1 | 1 | 5:5 | 0 | 7 |
| 8 |
|
Racing Club | 4 | 1 | 3 | 0 | 7:4 | 3 | 6 |
| 9 |
|
Newell's Old Boys | 4 | 2 | 0 | 2 | 3:6 | -3 | 6 |
| 10 |
|
Atlético Tucumán | 4 | 1 | 1 | 2 | 3:4 | -1 | 4 |
| 11 |
|
Gimnasia de La Plata | 4 | 1 | 1 | 2 | 3:7 | -4 | 4 |
| 12 |
|
San Lorenzo | 4 | 0 | 2 | 2 | 4:6 | -2 | 2 |
| 13 |
|
Talleres de Córdoba | 4 | 0 | 2 | 2 | 1:3 | -2 | 2 |
| 14 |
|
Patronato de Paraná | 4 | 0 | 1 | 3 | 1:6 | -5 | 1 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Estudiantes | 4 | 4 | 0 | 0 | 10:6 | 4 | 12 |
| 2 |
|
Colón de Santa Fe | 4 | 3 | 1 | 0 | 8:3 | 5 | 10 |
| 3 |
|
Boca Juniors | 4 | 2 | 2 | 0 | 7:5 | 2 | 8 |
| 4 |
|
Tigre | 4 | 1 | 3 | 0 | 4:2 | 2 | 6 |
| 5 |
|
Huracán | 4 | 2 | 0 | 2 | 6:5 | 1 | 6 |
| 6 |
|
Central Córdoba SdE | 4 | 1 | 2 | 1 | 4:4 | 0 | 5 |
|
Independiente | 4 | 1 | 2 | 1 | 4:4 | 0 | 5 | |
| 8 |
|
Lanús | 4 | 1 | 1 | 2 | 3:3 | 0 | 4 |
| 9 |
|
Arsenal de Sarandí | 4 | 1 | 1 | 2 | 5:6 | -1 | 4 |
| 10 |
|
Rosario Central | 4 | 1 | 1 | 2 | 4:5 | -1 | 4 |
| 11 |
|
Aldosivi | 4 | 1 | 1 | 2 | 3:4 | -1 | 4 |
| 12 |
|
Vélez Sarsfield | 4 | 1 | 1 | 2 | 2:3 | -1 | 4 |
| 13 |
|
Godoy Cruz | 4 | 1 | 1 | 2 | 4:7 | -3 | 4 |
| 14 |
|
Barracas Central | 4 | 0 | 0 | 4 | 2:9 | -7 | 0 |
| Play-offs | |
| Play-offs |
