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| 04.03.2022 | 01:30 | Central Córdoba SdE | - | Rosario Central | 0:1 (0:0) | |
| 23:15 | Unión de Santa Fe | - | Platense | 1:0 (0:0) | ||
| 05.03.2022 | 01:30 | Gimnasia de La Plata | - | Argentinos Juniors | 2:2 (1:1) | |
| 01:30 | Barracas Central | - | Aldosivi | 2:1 (0:1) | ||
| 21:00 | San Lorenzo | - | River Plate | 0:1 (0:1) | ||
| 23:15 | Patronato de Paraná | - | Sarmiento de Junín | 0:1 (0:1) | ||
| 06.03.2022 | 01:30 | Racing Club | - | Talleres de Córdoba | 1:0 (1:0) | |
| 21:00 | Banfield | - | Defensa y Justicia | 2:3 (1:2) | ||
| 21:00 | Newell's Old Boys | - | Atlético Tucumán | 4:0 (2:0) | ||
| 23:15 | Boca Juniors | - | Huracán | 0:1 (0:0) | ||
| 07.03.2022 | 01:30 | Vélez Sarsfield | - | Estudiantes | 1:1 (1:0) | |
| 21:00 | Godoy Cruz | - | Independiente | 3:3 (1:1) | ||
| 23:15 | Arsenal de Sarandí | - | Lanús | 2:2 (1:2) | ||
| 08.03.2022 | 01:30 | Tigre | - | Colón de Santa Fe | 1:0 (1:0) |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
River Plate | 5 | 3 | 1 | 1 | 9:4 | 5 | 10 |
| 2 |
|
Defensa y Justicia | 5 | 3 | 1 | 1 | 12:10 | 2 | 10 |
| 3 |
|
Unión de Santa Fe | 5 | 3 | 1 | 1 | 4:2 | 2 | 10 |
| 4 |
|
Sarmiento de Junín | 5 | 3 | 1 | 1 | 6:5 | 1 | 10 |
| 5 |
|
Racing Club | 5 | 2 | 3 | 0 | 8:4 | 4 | 9 |
| 6 |
|
Newell's Old Boys | 5 | 3 | 0 | 2 | 7:6 | 1 | 9 |
| 7 |
|
Banfield | 5 | 2 | 2 | 1 | 9:5 | 4 | 8 |
| 8 |
|
Argentinos Juniors | 5 | 2 | 2 | 1 | 7:6 | 1 | 8 |
| 9 |
|
Platense | 5 | 2 | 1 | 2 | 5:4 | 1 | 7 |
| 10 |
|
Gimnasia de La Plata | 5 | 1 | 2 | 2 | 5:9 | -4 | 5 |
| 11 |
|
Atlético Tucumán | 5 | 1 | 1 | 3 | 3:8 | -5 | 4 |
| 12 |
|
San Lorenzo | 5 | 0 | 2 | 3 | 4:7 | -3 | 2 |
| 13 |
|
Talleres de Córdoba | 5 | 0 | 2 | 3 | 1:4 | -3 | 2 |
| 14 |
|
Patronato de Paraná | 5 | 0 | 1 | 4 | 1:7 | -6 | 1 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Estudiantes | 5 | 4 | 1 | 0 | 11:7 | 4 | 13 |
| 2 |
|
Colón de Santa Fe | 5 | 3 | 1 | 1 | 8:4 | 4 | 10 |
| 3 |
|
Tigre | 5 | 2 | 3 | 0 | 5:2 | 3 | 9 |
| 4 |
|
Huracán | 5 | 3 | 0 | 2 | 7:5 | 2 | 9 |
| 5 |
|
Boca Juniors | 5 | 2 | 2 | 1 | 7:6 | 1 | 8 |
| 6 |
|
Rosario Central | 5 | 2 | 1 | 2 | 5:5 | 0 | 7 |
| 7 |
|
Independiente | 5 | 1 | 3 | 1 | 7:7 | 0 | 6 |
| 8 |
|
Lanús | 5 | 1 | 2 | 2 | 5:5 | 0 | 5 |
| 9 |
|
Arsenal de Sarandí | 5 | 1 | 2 | 2 | 7:8 | -1 | 5 |
| 10 |
|
Central Córdoba SdE | 5 | 1 | 2 | 2 | 4:5 | -1 | 5 |
| 11 |
|
Vélez Sarsfield | 5 | 1 | 2 | 2 | 3:4 | -1 | 5 |
| 12 |
|
Godoy Cruz | 5 | 1 | 2 | 2 | 7:10 | -3 | 5 |
| 13 |
|
Aldosivi | 5 | 1 | 1 | 3 | 4:6 | -2 | 4 |
| 14 |
|
Barracas Central | 5 | 1 | 0 | 4 | 4:10 | -6 | 3 |
| Play-offs | |
| Play-offs |
