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| 28.05.2022 | 18:05 | Armenio | - | Comunicaciones de Buenos Aires | 0:2 (0:0) | |
| 18:05 | Fénix | - | Ituzaingó | 2:1 (1:0) | ||
| 20:30 | Talleres (RdE) | - | Colegiales de Munro | 0:1 (0:1) | ||
| 20:30 | Defensores Unidos de Zárate | - | Acassuso | 4:1 (3:1) | ||
| 20:30 | Villa San Carlos | - | Argentino de Quilmes | 1:2 (1:0) | ||
| 20:30 | UAI Urquiza | - | Justo José de Urquiza | 1:2 (1:2) | ||
| 20:30 | Dock Sud | - | Cañuelas | 2:2 (2:2) | ||
| 20:30 | Atlético San Miguel | - | CA Los Andes | 1:1 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Comunicaciones de Buenos Aires | 15 | 9 | 3 | 3 | 27:13 | 14 | 30 |
| 2 |
|
Ituzaingó | 15 | 7 | 4 | 4 | 18:15 | 3 | 25 |
| 3 |
|
Fénix | 16 | 6 | 6 | 4 | 17:14 | 3 | 24 |
| 4 |
|
Colegiales de Munro | 15 | 7 | 3 | 5 | 21:19 | 2 | 24 |
| 5 |
|
Defensores Unidos de Zárate | 15 | 6 | 5 | 4 | 22:17 | 5 | 23 |
| 6 |
|
Cañuelas | 15 | 6 | 4 | 5 | 20:15 | 5 | 22 |
| 7 |
|
Villa San Carlos | 15 | 6 | 4 | 5 | 19:16 | 3 | 22 |
| 8 |
|
Talleres (RdE) | 15 | 6 | 4 | 5 | 18:17 | 1 | 22 |
| 9 |
|
Armenio | 15 | 5 | 7 | 3 | 15:15 | 0 | 22 |
| 10 |
|
Justo José de Urquiza | 15 | 4 | 8 | 3 | 16:13 | 3 | 20 |
| 11 |
|
Argentino de Quilmes | 15 | 4 | 6 | 5 | 17:18 | -1 | 18 |
| 12 |
|
Dock Sud | 15 | 4 | 5 | 6 | 16:20 | -4 | 17 |
| 13 |
|
Acassuso | 15 | 3 | 7 | 5 | 16:18 | -2 | 16 |
| 14 |
|
Deportivo Merlo | 15 | 4 | 4 | 7 | 10:16 | -6 | 16 |
| 15 |
|
UAI Urquiza | 15 | 4 | 3 | 8 | 16:25 | -9 | 15 |
| 16 |
|
CA Los Andes | 15 | 2 | 8 | 5 | 13:19 | -6 | 14 |
| 17 |
|
Atlético San Miguel | 15 | 3 | 3 | 9 | 11:22 | -11 | 12 |
| Play-offs |
