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| 10.04.2021 | 02:00 | Platense | - | San Lorenzo | 2:4 (2:2) | |
| 21:15 | Estudiantes | - | Aldosivi | 1:0 (0:0) | ||
| 23:30 | Defensa y Justicia | - | Talleres de Córdoba | 2:2 (1:1) | ||
| 11.04.2021 | 02:00 | Racing Club | - | Independiente | 1:0 (0:0) | |
| 16:00 | Godoy Cruz | - | Arsenal de Sarandí | 2:3 (0:1) | ||
| 19:00 | Argentinos Juniors | - | Central Córdoba SdE | 0:0 (0:0) | ||
| 19:00 | Patronato de Paraná | - | Gimnasia de La Plata | 4:1 (3:0) | ||
| 21:15 | Rosario Central | - | Banfield | 3:1 (1:1) | ||
| 23:30 | Unión de Santa Fe | - | Boca Juniors | 1:0 (0:0) | ||
| 12.04.2021 | 02:00 | River Plate | - | Colón de Santa Fe | 3:2 (1:1) | |
| 13.04.2021 | 00:00 | Huracán | - | Sarmiento de Junín | 3:0 (1:0) | |
| 00:00 | Lanús | - | Newell's Old Boys | 1:3 (1:1) | ||
| 02:15 | Atlético Tucumán | - | Vélez Sarsfield | 2:0 (1:0) |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Colón de Santa Fe | 9 | 6 | 2 | 1 | 17:5 | 12 | 20 |
| 2 |
|
River Plate | 9 | 4 | 3 | 2 | 15:7 | 8 | 15 |
| 3 |
|
Estudiantes | 9 | 4 | 3 | 2 | 13:8 | 5 | 15 |
| 4 |
|
Racing Club | 9 | 4 | 3 | 2 | 9:8 | 1 | 15 |
| 5 |
|
San Lorenzo | 9 | 4 | 2 | 3 | 12:12 | 0 | 14 |
| 6 |
|
Central Córdoba SdE | 9 | 3 | 4 | 2 | 12:10 | 2 | 13 |
| 7 |
|
Banfield | 9 | 3 | 4 | 2 | 11:10 | 1 | 13 |
| 8 |
|
Rosario Central | 9 | 3 | 3 | 3 | 11:13 | -2 | 12 |
| 9 |
|
Argentinos Juniors | 9 | 3 | 2 | 4 | 7:8 | -1 | 11 |
| 10 |
|
Godoy Cruz | 9 | 3 | 2 | 4 | 15:20 | -5 | 11 |
| 11 |
|
Aldosivi | 9 | 2 | 2 | 5 | 11:13 | -2 | 8 |
| 12 |
|
Platense | 9 | 2 | 2 | 5 | 7:14 | -7 | 8 |
| 13 |
|
Arsenal de Sarandí | 9 | 1 | 2 | 6 | 7:19 | -12 | 5 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Vélez Sarsfield | 9 | 6 | 1 | 2 | 13:12 | 1 | 19 |
| 2 |
|
Lanús | 9 | 5 | 1 | 3 | 16:14 | 2 | 16 |
| 3 |
|
Unión de Santa Fe | 9 | 3 | 5 | 1 | 10:10 | 0 | 14 |
| 4 |
|
Boca Juniors | 9 | 3 | 4 | 2 | 16:10 | 6 | 13 |
| 5 |
|
Independiente | 9 | 4 | 1 | 4 | 12:8 | 4 | 13 |
| 6 |
|
Talleres de Córdoba | 9 | 3 | 4 | 2 | 12:12 | 0 | 13 |
| 7 |
|
Huracán | 9 | 2 | 6 | 1 | 12:9 | 3 | 12 |
| 8 |
|
Defensa y Justicia | 9 | 3 | 3 | 3 | 15:13 | 2 | 12 |
| 9 |
|
Atlético Tucumán | 9 | 3 | 3 | 3 | 15:14 | 1 | 12 |
| 10 |
|
Gimnasia de La Plata | 9 | 2 | 4 | 3 | 13:14 | -1 | 10 |
| 11 |
|
Newell's Old Boys | 9 | 1 | 4 | 4 | 10:15 | -5 | 7 |
| 12 |
|
Sarmiento de Junín | 9 | 1 | 4 | 4 | 8:17 | -9 | 7 |
| 13 |
|
Patronato de Paraná | 9 | 2 | 0 | 7 | 10:14 | -4 | 6 |
| Play-offs | |
| Play-offs |
