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| 25.09.2021 | 00:00 | Sarmiento de Junín | - | Vélez Sarsfield | 0:1 (0:0) | |
| 02:15 | Estudiantes | - | Platense | 1:1 (1:0) | ||
| 18:30 | Aldosivi | - | Gimnasia de La Plata | 1:3 (0:2) | ||
| 20:45 | Arsenal de Sarandí | - | Lanús | 1:0 (0:0) | ||
| 20:45 | Talleres de Córdoba | - | Rosario Central | 4:1 (3:1) | ||
| 23:00 | Banfield | - | Atlético Tucumán | 2:0 (2:0) | ||
| 26.09.2021 | 01:15 | Central Córdoba SdE | - | River Plate | 1:3 (0:1) | |
| 18:30 | Unión de Santa Fe | - | Patronato de Paraná | 2:0 (0:0) | ||
| 20:45 | San Lorenzo | - | Defensa y Justicia | 2:1 (2:0) | ||
| 23:00 | Independiente | - | Godoy Cruz | 1:4 (0:2) | ||
| 27.09.2021 | 01:15 | Boca Juniors | - | Colón de Santa Fe | 1:0 (0:0) | |
| 23:00 | Argentinos Juniors | - | Racing Club | 2:0 (2:0) | ||
| 28.09.2021 | 01:15 | Newell's Old Boys | - | Huracán | 0:1 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Talleres de Córdoba | 13 | 9 | 2 | 2 | 22:10 | 12 | 29 |
| 2 |
|
River Plate | 13 | 8 | 3 | 2 | 26:10 | 16 | 27 |
| 3 |
|
Estudiantes | 13 | 7 | 3 | 3 | 21:12 | 9 | 24 |
| 4 |
|
Lanús | 13 | 7 | 2 | 4 | 22:19 | 3 | 23 |
| 5 |
|
Independiente | 13 | 6 | 4 | 3 | 13:10 | 3 | 22 |
| 6 |
|
Boca Juniors | 13 | 5 | 6 | 2 | 11:8 | 3 | 21 |
| 7 |
|
Vélez Sarsfield | 13 | 5 | 5 | 3 | 17:8 | 9 | 20 |
| 8 |
|
Godoy Cruz | 13 | 6 | 2 | 5 | 23:18 | 5 | 20 |
| 9 |
|
Colón de Santa Fe | 13 | 5 | 4 | 4 | 10:15 | -5 | 19 |
| 10 |
|
Racing Club | 13 | 4 | 6 | 3 | 10:6 | 4 | 18 |
| 11 |
|
Argentinos Juniors | 13 | 4 | 6 | 3 | 11:8 | 3 | 18 |
| 12 |
|
Gimnasia de La Plata | 13 | 4 | 5 | 4 | 11:14 | -3 | 17 |
| 13 |
|
Huracán | 13 | 3 | 7 | 3 | 9:8 | 1 | 16 |
| 14 |
|
Rosario Central | 13 | 5 | 1 | 7 | 18:18 | 0 | 16 |
| 15 |
|
San Lorenzo | 13 | 4 | 4 | 5 | 12:15 | -3 | 16 |
| 16 |
|
Defensa y Justicia | 13 | 3 | 6 | 4 | 13:12 | 1 | 15 |
| 17 |
|
Newell's Old Boys | 13 | 4 | 3 | 6 | 14:19 | -5 | 15 |
| 18 |
|
Unión de Santa Fe | 13 | 4 | 3 | 6 | 12:17 | -5 | 15 |
| 19 |
|
Atlético Tucumán | 13 | 4 | 3 | 6 | 12:18 | -6 | 15 |
| 20 |
|
Patronato de Paraná | 13 | 3 | 5 | 5 | 10:14 | -4 | 14 |
| 21 |
|
Banfield | 13 | 2 | 7 | 4 | 10:13 | -3 | 13 |
| 22 |
|
Sarmiento de Junín | 13 | 3 | 4 | 6 | 11:16 | -5 | 13 |
| 23 |
|
Aldosivi | 13 | 4 | 1 | 8 | 15:24 | -9 | 13 |
| 24 |
|
Platense | 13 | 2 | 6 | 5 | 15:18 | -3 | 12 |
| 25 |
|
Central Córdoba SdE | 13 | 2 | 5 | 6 | 13:18 | -5 | 11 |
| 26 |
|
Arsenal de Sarandí | 13 | 2 | 5 | 6 | 6:19 | -13 | 11 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
