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| 31.07.2021 | 18:30 | Colón de Santa Fe | - | Godoy Cruz | 1:0 (0:0) | |
| 20:45 | Lanús | - | Unión de Santa Fe | 1:1 (1:0) | ||
| 23:00 | Racing Club | - | Sarmiento de Junín | 1:0 (0:0) | ||
| 01.08.2021 | 01:15 | Platense | - | Independiente | 1:1 (1:1) | |
| 18:30 | Defensa y Justicia | - | Gimnasia de La Plata | 3:2 (0:0) | ||
| 20:45 | Talleres de Córdoba | - | Boca Juniors | 0:0 (0:0) | ||
| 23:00 | River Plate | - | Huracán | 1:1 (0:0) | ||
| 02.08.2021 | 01:15 | San Lorenzo | - | Banfield | 1:1 (0:0) | |
| 21:45 | Argentinos Juniors | - | Central Córdoba SdE | 1:1 (0:1) | ||
| 21:45 | Patronato de Paraná | - | Newell's Old Boys | 0:0 (0:0) | ||
| 03.08.2021 | 00:00 | Estudiantes | - | Arsenal de Sarandí | 4:0 (0:0) | |
| 00:00 | Rosario Central | - | Aldosivi | 1:2 (0:1) | ||
| 02:15 | Atlético Tucumán | - | Vélez Sarsfield | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
San Lorenzo | 4 | 2 | 2 | 0 | 5:2 | 3 | 8 |
| 2 |
|
Independiente | 4 | 2 | 2 | 0 | 4:1 | 3 | 8 |
| 3 |
|
Racing Club | 4 | 2 | 2 | 0 | 3:0 | 3 | 8 |
| 4 |
|
River Plate | 4 | 2 | 1 | 1 | 9:3 | 6 | 7 |
| 5 |
|
Lanús | 4 | 2 | 1 | 1 | 9:7 | 2 | 7 |
| 6 |
|
Newell's Old Boys | 4 | 2 | 1 | 1 | 7:5 | 2 | 7 |
| 7 |
|
Patronato de Paraná | 4 | 2 | 1 | 1 | 4:2 | 2 | 7 |
| 8 |
|
Atlético Tucumán | 4 | 2 | 1 | 1 | 5:5 | 0 | 7 |
| 9 |
|
Colón de Santa Fe | 4 | 2 | 1 | 1 | 5:6 | -1 | 7 |
| 10 |
|
Estudiantes | 4 | 2 | 0 | 2 | 9:5 | 4 | 6 |
| 11 |
|
Banfield | 4 | 1 | 3 | 0 | 3:2 | 1 | 6 |
| 12 |
|
Godoy Cruz | 4 | 2 | 0 | 2 | 5:5 | 0 | 6 |
| 13 |
|
Aldosivi | 4 | 2 | 0 | 2 | 3:5 | -2 | 6 |
| 14 |
|
Gimnasia de La Plata | 4 | 1 | 2 | 1 | 5:5 | 0 | 5 |
| 15 |
|
Central Córdoba SdE | 4 | 1 | 2 | 1 | 4:4 | 0 | 5 |
|
Huracán | 4 | 1 | 2 | 1 | 4:4 | 0 | 5 | |
| 17 |
|
Argentinos Juniors | 4 | 1 | 2 | 1 | 2:2 | 0 | 5 |
| 18 |
|
Talleres de Córdoba | 4 | 1 | 1 | 2 | 5:5 | 0 | 4 |
| 19 |
|
Defensa y Justicia | 4 | 1 | 1 | 2 | 5:6 | -1 | 4 |
| 20 |
|
Arsenal de Sarandí | 4 | 1 | 1 | 2 | 2:7 | -5 | 4 |
| 21 |
|
Vélez Sarsfield | 4 | 0 | 3 | 1 | 0:1 | -1 | 3 |
| 22 |
|
Rosario Central | 4 | 1 | 0 | 3 | 3:5 | -2 | 3 |
| 23 |
|
Boca Juniors | 4 | 0 | 3 | 1 | 1:3 | -2 | 3 |
| 24 |
|
Sarmiento de Junín | 4 | 1 | 0 | 3 | 1:6 | -5 | 3 |
| 25 |
|
Platense | 4 | 0 | 2 | 2 | 3:5 | -2 | 2 |
| 26 |
|
Unión de Santa Fe | 4 | 0 | 2 | 2 | 2:7 | -5 | 2 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
