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| 17.09.2022 | 20:30 | Barracas Central | - | Godoy Cruz | 3:1 (1:0) | |
| 18.09.2022 | 01:30 | Newell's Old Boys | - | Sarmiento de Junín | 0:1 (0:0) | |
| 18:00 | Tigre | - | Vélez Sarsfield | 2:0 (2:0) | ||
| 20:30 | San Lorenzo | - | River Plate | 0:1 (0:1) | ||
| 23:00 | Banfield | - | Lanús | 1:2 (0:1) | ||
| 19.09.2022 | 01:30 | Platense | - | Racing Club | 0:1 (0:0) | |
| 01:30 | Talleres de Córdoba | - | Colón de Santa Fe | 2:0 (2:0) | ||
| 21:30 | Arsenal de Sarandí | - | Aldosivi | 3:0 (2:0) | ||
| 20.09.2022 | 00:00 | Boca Juniors | - | Huracán | 0:0 (0:0) | |
| 00:00 | Unión de Santa Fe | - | Independiente | 0:1 (0:0) | ||
| 02:30 | Argentinos Juniors | - | Atlético Tucumán | 1:2 (0:2) | ||
| 02:30 | Estudiantes | - | Defensa y Justicia | 1:2 (0:1) | ||
| 23:00 | Patronato de Paraná | - | Rosario Central | 0:0 (0:0) | ||
| 21.09.2022 | 01:30 | Central Córdoba SdE | - | Gimnasia de La Plata | 1:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético Tucumán | 20 | 10 | 8 | 2 | 23:11 | 12 | 38 |
| 2 |
|
Gimnasia de La Plata | 20 | 10 | 6 | 4 | 21:11 | 10 | 36 |
| 3 |
|
Boca Juniors | 20 | 11 | 3 | 6 | 25:22 | 3 | 36 |
| 4 |
|
Racing Club | 20 | 9 | 7 | 4 | 26:15 | 11 | 34 |
| 5 |
|
Huracán | 20 | 8 | 10 | 2 | 23:14 | 9 | 34 |
| 6 |
|
River Plate | 20 | 9 | 5 | 6 | 29:17 | 12 | 32 |
| 7 |
|
Godoy Cruz | 20 | 9 | 5 | 6 | 23:21 | 2 | 32 |
| 8 |
|
Argentinos Juniors | 20 | 9 | 3 | 8 | 22:20 | 2 | 30 |
| 9 |
|
Platense | 20 | 7 | 8 | 5 | 18:15 | 3 | 29 |
| 10 |
|
Newell's Old Boys | 20 | 8 | 5 | 7 | 19:18 | 1 | 29 |
| 11 |
|
Patronato de Paraná | 20 | 7 | 7 | 6 | 23:20 | 3 | 28 |
| 12 |
|
Tigre | 20 | 6 | 9 | 5 | 28:24 | 4 | 27 |
| 13 |
|
San Lorenzo | 20 | 5 | 12 | 3 | 23:19 | 4 | 27 |
| 14 |
|
Estudiantes | 20 | 7 | 6 | 7 | 19:20 | -1 | 27 |
| 15 |
|
Unión de Santa Fe | 20 | 7 | 6 | 7 | 23:26 | -3 | 27 |
| 16 |
|
Barracas Central | 20 | 7 | 6 | 7 | 24:28 | -4 | 27 |
| 17 |
|
Banfield | 20 | 6 | 7 | 7 | 20:21 | -1 | 25 |
| 18 |
|
Defensa y Justicia | 20 | 6 | 7 | 7 | 18:21 | -3 | 25 |
| 19 |
|
Sarmiento de Junín | 20 | 7 | 4 | 9 | 20:24 | -4 | 25 |
| 20 |
|
Independiente | 20 | 6 | 6 | 8 | 22:23 | -1 | 24 |
| 21 |
|
Central Córdoba SdE | 20 | 7 | 3 | 10 | 24:28 | -4 | 24 |
| 22 |
|
Rosario Central | 20 | 6 | 6 | 8 | 15:19 | -4 | 24 |
| 23 |
|
Arsenal de Sarandí | 20 | 4 | 11 | 5 | 21:22 | -1 | 23 |
| 24 |
|
Talleres de Córdoba | 20 | 5 | 8 | 7 | 18:19 | -1 | 23 |
| 25 |
|
Colón de Santa Fe | 20 | 4 | 7 | 9 | 15:24 | -9 | 19 |
| 26 |
|
Vélez Sarsfield | 20 | 2 | 10 | 8 | 22:28 | -6 | 16 |
| 27 |
|
Lanús | 20 | 3 | 5 | 12 | 17:30 | -13 | 14 |
| 28 |
|
Aldosivi | 20 | 3 | 4 | 13 | 12:33 | -21 | 13 |
