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| 08.10.2022 | 18:00 | Barracas Central | - | Sarmiento de Junín | 1:1 (0:0) | |
| 21:00 | San Lorenzo | - | Vélez Sarsfield | 1:0 (0:0) | ||
| 23:15 | Unión de Santa Fe | - | Arsenal de Sarandí | 1:0 (0:0) | ||
| 09.10.2022 | 01:30 | Platense | - | Colón de Santa Fe | 1:2 (0:0) | |
| 18:00 | Tigre | - | Independiente | 2:1 (2:1) | ||
| 20:30 | Banfield | - | Gimnasia de La Plata | 0:2 (0:2) | ||
| 20:30 | Talleres de Córdoba | - | Godoy Cruz | 3:1 (2:1) | ||
| 23:00 | Boca Juniors | - | Aldosivi | 2:1 (2:1) | ||
| 10.10.2022 | 01:30 | Patronato de Paraná | - | River Plate | 0:1 (0:0) | |
| 21:30 | Argentinos Juniors | - | Huracán | 1:1 (0:1) | ||
| 21:30 | Rosario Central | - | Defensa y Justicia | 0:0 (0:0) | ||
| 11.10.2022 | 00:00 | Estudiantes | - | Lanús | 3:1 (2:0) | |
| 00:00 | Racing Club | - | Atlético Tucumán | 2:0 (2:0) | ||
| 02:30 | Central Córdoba SdE | - | Newell's Old Boys | 0:3 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors | 24 | 15 | 3 | 6 | 31:24 | 7 | 48 |
| 2 |
|
Racing Club | 24 | 12 | 8 | 4 | 37:22 | 15 | 44 |
| 3 |
|
Atlético Tucumán | 24 | 12 | 8 | 4 | 29:17 | 12 | 44 |
| 4 |
|
River Plate | 24 | 12 | 5 | 7 | 38:18 | 20 | 41 |
| 5 |
|
Huracán | 24 | 10 | 11 | 3 | 28:17 | 11 | 41 |
| 6 |
|
Gimnasia de La Plata | 24 | 11 | 7 | 6 | 25:15 | 10 | 40 |
| 7 |
|
Tigre | 24 | 9 | 10 | 5 | 36:27 | 9 | 37 |
| 8 |
|
Argentinos Juniors | 24 | 11 | 4 | 9 | 31:24 | 7 | 37 |
| 9 |
|
Newell's Old Boys | 24 | 10 | 6 | 8 | 23:19 | 4 | 36 |
| 10 |
|
San Lorenzo | 24 | 7 | 13 | 4 | 25:21 | 4 | 34 |
| 11 |
|
Godoy Cruz | 24 | 9 | 7 | 8 | 25:26 | -1 | 34 |
| 12 |
|
Patronato de Paraná | 24 | 8 | 7 | 9 | 26:25 | 1 | 31 |
| 13 |
|
Platense | 24 | 7 | 10 | 7 | 21:20 | 1 | 31 |
| 14 |
|
Sarmiento de Junín | 24 | 8 | 7 | 9 | 25:27 | -2 | 31 |
| 15 |
|
Defensa y Justicia | 24 | 7 | 10 | 7 | 23:25 | -2 | 31 |
| 16 |
|
Central Córdoba SdE | 24 | 9 | 4 | 11 | 29:32 | -3 | 31 |
| 17 |
|
Unión de Santa Fe | 24 | 8 | 7 | 9 | 26:30 | -4 | 31 |
| 18 |
|
Independiente | 24 | 8 | 6 | 10 | 26:27 | -1 | 30 |
| 19 |
|
Estudiantes | 24 | 8 | 6 | 10 | 25:33 | -8 | 30 |
| 20 |
|
Talleres de Córdoba | 24 | 7 | 8 | 9 | 22:22 | 0 | 29 |
| 21 |
|
Barracas Central | 24 | 7 | 8 | 9 | 26:33 | -7 | 29 |
| 22 |
|
Colón de Santa Fe | 24 | 7 | 7 | 10 | 22:31 | -9 | 28 |
| 23 |
|
Rosario Central | 24 | 6 | 9 | 9 | 20:25 | -5 | 27 |
| 24 |
|
Banfield | 24 | 6 | 8 | 10 | 22:28 | -6 | 26 |
| 25 |
|
Arsenal de Sarandí | 24 | 4 | 12 | 8 | 21:26 | -5 | 24 |
| 26 |
|
Vélez Sarsfield | 24 | 4 | 10 | 10 | 24:30 | -6 | 22 |
| 27 |
|
Lanús | 24 | 5 | 5 | 14 | 21:37 | -16 | 20 |
| 28 |
|
Aldosivi | 24 | 4 | 4 | 16 | 15:41 | -26 | 16 |
