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| 12.10.2022 | 19:00 | Aldosivi | - | Banfield | 0:1 (0:1) | |
| 21:30 | Sarmiento de Junín | - | Boca Juniors | 0:1 (0:1) | ||
| 21:30 | Gimnasia de La Plata | - | San Lorenzo | 0:1 (0:0) | ||
| 13.10.2022 | 00:00 | Independiente | - | Barracas Central | 2:2 (1:1) | |
| 02:30 | River Plate | - | Platense | 2:1 (0:0) | ||
| 21:30 | Vélez Sarsfield | - | Talleres de Córdoba | 2:1 (0:0) | ||
| 14.10.2022 | 00:00 | Lanús | - | Patronato de Paraná | 0:1 (0:0) | |
| 00:00 | Godoy Cruz | - | Argentinos Juniors | 0:0 (0:0) | ||
| 02:30 | Atlético Tucumán | - | Rosario Central | 1:1 (0:1) | ||
| 02:30 | Newell's Old Boys | - | Tigre | 0:2 (0:2) | ||
| 21:30 | Colón de Santa Fe | - | Racing Club | 0:2 (0:0) | ||
| 15.10.2022 | 00:00 | Huracán | - | Estudiantes | 3:1 (1:1) | |
| 00:00 | Defensa y Justicia | - | Unión de Santa Fe | 1:0 (1:0) | ||
| 02:30 | Arsenal de Sarandí | - | Central Córdoba SdE | 2:0 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors | 25 | 16 | 3 | 6 | 32:24 | 8 | 51 |
| 2 |
|
Racing Club | 25 | 13 | 8 | 4 | 39:22 | 17 | 47 |
| 3 |
|
Atlético Tucumán | 25 | 12 | 9 | 4 | 30:18 | 12 | 45 |
| 4 |
|
River Plate | 25 | 13 | 5 | 7 | 40:19 | 21 | 44 |
| 5 |
|
Huracán | 25 | 11 | 11 | 3 | 31:18 | 13 | 44 |
| 6 |
|
Tigre | 25 | 10 | 10 | 5 | 38:27 | 11 | 40 |
| 7 |
|
Gimnasia de La Plata | 25 | 11 | 7 | 7 | 25:16 | 9 | 40 |
| 8 |
|
Argentinos Juniors | 25 | 11 | 5 | 9 | 31:24 | 7 | 38 |
| 9 |
|
San Lorenzo | 25 | 8 | 13 | 4 | 26:21 | 5 | 37 |
| 10 |
|
Newell's Old Boys | 25 | 10 | 6 | 9 | 23:21 | 2 | 36 |
| 11 |
|
Godoy Cruz | 25 | 9 | 8 | 8 | 25:26 | -1 | 35 |
| 12 |
|
Patronato de Paraná | 25 | 9 | 7 | 9 | 27:25 | 2 | 34 |
| 13 |
|
Defensa y Justicia | 25 | 8 | 10 | 7 | 24:25 | -1 | 34 |
| 14 |
|
Platense | 25 | 7 | 10 | 8 | 22:22 | 0 | 31 |
| 15 |
|
Independiente | 25 | 8 | 7 | 10 | 28:29 | -1 | 31 |
| 16 |
|
Sarmiento de Junín | 25 | 8 | 7 | 10 | 25:28 | -3 | 31 |
| 17 |
|
Central Córdoba SdE | 25 | 9 | 4 | 12 | 29:34 | -5 | 31 |
| 18 |
|
Unión de Santa Fe | 25 | 8 | 7 | 10 | 26:31 | -5 | 31 |
| 19 |
|
Barracas Central | 25 | 7 | 9 | 9 | 28:35 | -7 | 30 |
| 20 |
|
Estudiantes | 25 | 8 | 6 | 11 | 26:36 | -10 | 30 |
| 21 |
|
Talleres de Córdoba | 25 | 7 | 8 | 10 | 23:24 | -1 | 29 |
| 22 |
|
Banfield | 25 | 7 | 8 | 10 | 23:28 | -5 | 29 |
| 23 |
|
Rosario Central | 25 | 6 | 10 | 9 | 21:26 | -5 | 28 |
| 24 |
|
Colón de Santa Fe | 25 | 7 | 7 | 11 | 22:33 | -11 | 28 |
| 25 |
|
Arsenal de Sarandí | 25 | 5 | 12 | 8 | 23:26 | -3 | 27 |
| 26 |
|
Vélez Sarsfield | 25 | 5 | 10 | 10 | 26:31 | -5 | 25 |
| 27 |
|
Lanús | 25 | 5 | 5 | 15 | 21:38 | -17 | 20 |
| 28 |
|
Aldosivi | 25 | 4 | 4 | 17 | 15:42 | -27 | 16 |
