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| 18.06.2022 | 23:00 | Arsenal de Sarandí | - | Talleres de Córdoba | 1:1 (1:0) | |
| 19.06.2022 | 01:30 | Sarmiento de Junín | - | Patronato de Paraná | 3:1 (1:1) | |
| 18:00 | Tigre | - | Banfield | 0:1 (0:0) | ||
| 20:30 | Huracán | - | Atlético Tucumán | 0:0 (0:0) | ||
| 20:30 | Lanús | - | Colón de Santa Fe | 1:0 (0:0) | ||
| 23:00 | Unión de Santa Fe | - | River Plate | 1:5 (0:1) | ||
| 20.06.2022 | 02:30 | Barracas Central | - | Boca Juniors | 1:3 (1:1) | |
| 21:30 | Godoy Cruz | - | Defensa y Justicia | 2:1 (2:1) | ||
| 21.06.2022 | 00:00 | Gimnasia de La Plata | - | Racing Club | 3:1 (2:1) | |
| 00:00 | Vélez Sarsfield | - | Rosario Central | 2:0 (1:0) | ||
| 02:30 | Independiente | - | Estudiantes | 2:1 (0:0) | ||
| 02:30 | Newell's Old Boys | - | Argentinos Juniors | 1:0 (1:0) | ||
| 22.06.2022 | 00:00 | Aldosivi | - | Platense | 0:0 (0:0) | |
| 02:30 | Central Córdoba SdE | - | San Lorenzo | 0:2 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Newell's Old Boys | 4 | 3 | 1 | 0 | 4:1 | 3 | 10 |
| 2 |
|
Boca Juniors | 4 | 3 | 0 | 1 | 10:6 | 4 | 9 |
| 3 |
|
Gimnasia de La Plata | 4 | 2 | 2 | 0 | 7:3 | 4 | 8 |
| 4 |
|
Platense | 4 | 2 | 2 | 0 | 4:2 | 2 | 8 |
| 5 |
|
Estudiantes | 4 | 2 | 1 | 1 | 5:4 | 1 | 7 |
|
Independiente | 4 | 2 | 1 | 1 | 5:4 | 1 | 7 | |
| 7 |
|
Banfield | 4 | 2 | 1 | 1 | 4:3 | 1 | 7 |
| 8 |
|
San Lorenzo | 4 | 1 | 3 | 0 | 6:4 | 2 | 6 |
| 9 |
|
Godoy Cruz | 4 | 2 | 0 | 2 | 5:4 | 1 | 6 |
| 10 |
|
Atlético Tucumán | 4 | 1 | 3 | 0 | 3:2 | 1 | 6 |
| 11 |
|
Racing Club | 4 | 2 | 0 | 2 | 5:5 | 0 | 6 |
|
Sarmiento de Junín | 4 | 2 | 0 | 2 | 5:5 | 0 | 6 | |
| 13 |
|
Argentinos Juniors | 4 | 2 | 0 | 2 | 4:4 | 0 | 6 |
| 14 |
|
River Plate | 4 | 1 | 2 | 1 | 5:2 | 3 | 5 |
| 15 |
|
Colón de Santa Fe | 4 | 1 | 2 | 1 | 4:4 | 0 | 5 |
| 16 |
|
Huracán | 4 | 1 | 2 | 1 | 3:3 | 0 | 5 |
|
Lanús | 4 | 1 | 2 | 1 | 3:3 | 0 | 5 | |
| 18 |
|
Talleres de Córdoba | 4 | 1 | 1 | 2 | 3:3 | 0 | 4 |
| 19 |
|
Vélez Sarsfield | 4 | 1 | 1 | 2 | 3:4 | -1 | 4 |
| 20 |
|
Tigre | 4 | 1 | 1 | 2 | 6:8 | -2 | 4 |
| 21 |
|
Central Córdoba SdE | 4 | 1 | 1 | 2 | 3:5 | -2 | 4 |
| 22 |
|
Patronato de Paraná | 4 | 1 | 1 | 2 | 3:6 | -3 | 4 |
| 23 |
|
Rosario Central | 4 | 1 | 1 | 2 | 1:4 | -3 | 4 |
| 24 |
|
Unión de Santa Fe | 4 | 1 | 1 | 2 | 6:10 | -4 | 4 |
| 25 |
|
Arsenal de Sarandí | 4 | 0 | 3 | 1 | 5:6 | -1 | 3 |
| 26 |
|
Defensa y Justicia | 4 | 0 | 3 | 1 | 3:4 | -1 | 3 |
| 27 |
|
Barracas Central | 4 | 0 | 2 | 2 | 4:7 | -3 | 2 |
| 28 |
|
Aldosivi | 4 | 0 | 1 | 3 | 1:4 | -3 | 1 |
