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| 23.04.2021 | 14:00 | Atlético Tucumán II | - | Talleres de Córdoba II | 2:2 (1:1) | |
| 14:00 | Defensa y Justicia II | - | Arsenal de Sarandí II | 1:0 (1:0) | ||
| 14:00 | Gimnasia de La Plata II | - | Newell's Old Boys II | 0:0 (0:0) | ||
| 14:00 | Lanús II | - | Vélez Sarsfield II | 1:2 (0:1) | ||
| 14:00 | Huracán II | - | Boca Juniors II | 1:4 (0:2) | ||
| 14:00 | Unión de Santa Fe II | - | Independiente II | 1:1 (1:1) | ||
| 14:00 | Rosario Central II | - | Estudiantes II | 1:3 (0:1) | ||
| 14:00 | Platense II | - | Aldosivi II | 3:2 (2:2) | ||
| 14:00 | Argentinos Juniors II | - | Banfield II | 3:0 (1:0) | ||
| 14:00 | River Plate II | - | San Lorenzo II | 2:1 (0:1) | ||
| 14:00 | Godoy Cruz II | - | Central Córdoba SdE II | 1:0 (0:0) | ||
| 14:00 | Racing Club II | - | Colón de Santa Fe II | 0:1 (0:0) | ||
| 26.04.2021 | 15:00 | Patronato de Paraná II | - | Sarmiento de Junín II | 0:1 (0:1) |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
River Plate II | 11 | 9 | 2 | 0 | 22:6 | 16 | 29 |
| 2 |
|
Argentinos Juniors II | 11 | 6 | 4 | 1 | 14:4 | 10 | 22 |
| 3 |
|
Estudiantes II | 11 | 6 | 2 | 3 | 16:11 | 5 | 20 |
| 4 |
|
Godoy Cruz II | 11 | 5 | 4 | 2 | 12:7 | 5 | 19 |
| 5 |
|
Aldosivi II | 11 | 5 | 0 | 6 | 18:15 | 3 | 15 |
| 6 |
|
Rosario Central II | 11 | 3 | 5 | 3 | 15:11 | 4 | 14 |
| 7 |
|
Banfield II | 11 | 3 | 5 | 3 | 12:14 | -2 | 14 |
| 8 |
|
Racing Club II | 11 | 4 | 2 | 5 | 10:12 | -2 | 14 |
| 9 |
|
Platense II | 11 | 3 | 4 | 4 | 18:16 | 2 | 13 |
| 10 |
|
San Lorenzo II | 11 | 2 | 4 | 5 | 13:17 | -4 | 10 |
| 11 |
|
Colón de Santa Fe II | 11 | 2 | 4 | 5 | 7:17 | -10 | 10 |
| 12 |
|
Central Córdoba SdE II | 11 | 2 | 1 | 8 | 7:23 | -16 | 7 |
| 13 |
|
Arsenal de Sarandí II | 11 | 0 | 6 | 5 | 10:20 | -10 | 6 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors II | 11 | 7 | 3 | 1 | 23:11 | 12 | 24 |
| 2 |
|
Sarmiento de Junín II | 11 | 7 | 2 | 2 | 25:17 | 8 | 23 |
| 3 |
|
Independiente II | 11 | 5 | 3 | 3 | 22:17 | 5 | 18 |
| 4 |
|
Newell's Old Boys II | 11 | 5 | 2 | 4 | 19:17 | 2 | 17 |
| 5 |
|
Defensa y Justicia II | 11 | 4 | 4 | 3 | 18:16 | 2 | 16 |
| 6 |
|
Vélez Sarsfield II | 11 | 4 | 3 | 4 | 16:14 | 2 | 15 |
| 7 |
|
Unión de Santa Fe II | 11 | 4 | 3 | 4 | 17:17 | 0 | 15 |
| 8 |
|
Huracán II | 11 | 3 | 5 | 3 | 16:20 | -4 | 14 |
| 9 |
|
Gimnasia de La Plata II | 11 | 3 | 4 | 4 | 12:13 | -1 | 13 |
| 10 |
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Atlético Tucumán II | 11 | 3 | 3 | 5 | 17:19 | -2 | 12 |
| 11 |
|
Patronato de Paraná II | 11 | 2 | 4 | 5 | 8:15 | -7 | 10 |
| 12 |
|
Lanús II | 11 | 2 | 2 | 7 | 19:27 | -8 | 8 |
| 13 |
|
Talleres de Córdoba II | 11 | 1 | 5 | 5 | 13:23 | -10 | 8 |
| Play-offs | |
| Play-offs |
