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| 09.04.2021 | 15:00 | Unión de Santa Fe II | - | Boca Juniors II | 2:3 (1:1) | |
| 15:00 | Racing Club II | - | Independiente II | 3:1 (2:0) | ||
| 15:00 | Lanús II | - | Newell's Old Boys II | 4:6 (1:5) | ||
| 15:00 | Huracán II | - | Sarmiento de Junín II | 1:1 (0:1) | ||
| 15:00 | Atlético Tucumán II | - | Vélez Sarsfield II | 3:1 (1:0) | ||
| 15:00 | Estudiantes II | - | Aldosivi II | 2:0 (1:0) | ||
| 15:00 | Defensa y Justicia II | - | Talleres de Córdoba II | 5:1 (3:0) | ||
| 15:00 | Rosario Central II | - | Banfield II | 1:1 (0:0) | ||
| 15:00 | Platense II | - | San Lorenzo II | 2:0 (0:0) | ||
| 15:00 | River Plate II | - | Colón de Santa Fe II | 7:0 (4:0) | ||
| 17:00 | Godoy Cruz II | - | Arsenal de Sarandí II | 2:2 (0:0) | ||
| 20:00 | Argentinos Juniors II | - | Central Córdoba SdE II | 3:0 (3:0) | ||
| 03.05.2021 | 15:00 | Patronato de Paraná II | - | Gimnasia de La Plata II | 0:0 (0:0) |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
River Plate II | 9 | 7 | 2 | 0 | 18:4 | 14 | 23 |
| 2 |
|
Argentinos Juniors II | 9 | 5 | 3 | 1 | 9:2 | 7 | 18 |
| 3 |
|
Aldosivi II | 9 | 5 | 0 | 4 | 15:9 | 6 | 15 |
| 4 |
|
Estudiantes II | 9 | 4 | 2 | 3 | 11:10 | 1 | 14 |
| 5 |
|
Godoy Cruz II | 9 | 3 | 4 | 2 | 9:6 | 3 | 13 |
| 6 |
|
Banfield II | 9 | 3 | 4 | 2 | 10:9 | 1 | 13 |
| 7 |
|
Racing Club II | 9 | 4 | 1 | 4 | 9:10 | -1 | 13 |
| 8 |
|
Rosario Central II | 9 | 2 | 5 | 2 | 11:7 | 4 | 11 |
| 9 |
|
Platense II | 9 | 2 | 3 | 4 | 13:12 | 1 | 9 |
| 10 |
|
San Lorenzo II | 9 | 2 | 3 | 4 | 10:13 | -3 | 9 |
| 11 |
|
Colón de Santa Fe II | 9 | 1 | 4 | 4 | 5:15 | -10 | 7 |
| 12 |
|
Central Córdoba SdE II | 9 | 2 | 1 | 6 | 6:20 | -14 | 7 |
| 13 |
|
Arsenal de Sarandí II | 9 | 0 | 5 | 4 | 9:18 | -9 | 5 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors II | 9 | 5 | 3 | 1 | 16:9 | 7 | 18 |
| 2 |
|
Independiente II | 9 | 5 | 2 | 2 | 19:13 | 6 | 17 |
| 3 |
|
Sarmiento de Junín II | 9 | 5 | 2 | 2 | 20:16 | 4 | 17 |
| 4 |
|
Huracán II | 9 | 3 | 5 | 1 | 15:14 | 1 | 14 |
| 5 |
|
Newell's Old Boys II | 9 | 4 | 1 | 4 | 18:17 | 1 | 13 |
| 6 |
|
Unión de Santa Fe II | 9 | 4 | 1 | 4 | 16:16 | 0 | 13 |
| 7 |
|
Gimnasia de La Plata II | 9 | 3 | 3 | 3 | 12:11 | 1 | 12 |
| 8 |
|
Atlético Tucumán II | 9 | 3 | 2 | 4 | 14:14 | 0 | 11 |
| 9 |
|
Defensa y Justicia II | 9 | 2 | 4 | 3 | 14:14 | 0 | 10 |
| 10 |
|
Patronato de Paraná II | 9 | 2 | 4 | 3 | 8:13 | -5 | 10 |
| 11 |
|
Vélez Sarsfield II | 9 | 2 | 3 | 4 | 12:13 | -1 | 9 |
| 12 |
|
Lanús II | 9 | 2 | 2 | 5 | 17:21 | -4 | 8 |
| 13 |
|
Talleres de Córdoba II | 9 | 1 | 3 | 5 | 11:21 | -10 | 6 |
| Play-offs | |
| Play-offs |
