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| 13.08.2022 | 19:30 | Juventud Unida de Gualeguaychú | - | Belgrano de San Francisco | 1:1 (1:1) | |
| 20:00 | Crucero del Norte | - | Defensores Belgrano (VR) | 1:1 (0:0) | ||
| 21:00 | Boca Unidos | - | Sarmiento de Resistencia | 1:3 (1:1) | ||
| 14.08.2022 | 20:30 | Gimnasia y Esgrima (CdU) | - | Racing de Córdoba | 0:2 (0:2) | |
| 21:00 | Gimnasia y Tiro de Salta | - | Defensores de Pronunciamiento | 1:0 (1:0) | ||
| 21:00 | Sportivo Las Parejas | - | Central Norte | 0:1 (0:0) | ||
| 23:00 | Atlético Paraná | - | San Martín de Formosa | 0:1 (0:0) | ||
| 15.08.2022 | 01:00 | Juventud Antoniana | - | Douglas Haig | 1:1 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing de Córdoba | 23 | 14 | 8 | 1 | 42:12 | 30 | 50 |
| 2 |
|
Sarmiento de Resistencia | 23 | 13 | 8 | 2 | 34:12 | 22 | 47 |
| 3 |
|
San Martín de Formosa | 22 | 12 | 5 | 5 | 39:21 | 18 | 41 |
| 4 |
|
Central Norte | 22 | 11 | 8 | 3 | 31:17 | 14 | 41 |
| 5 |
|
Gimnasia y Tiro de Salta | 23 | 11 | 4 | 8 | 22:25 | -3 | 37 |
| 6 |
|
Douglas Haig | 23 | 10 | 6 | 7 | 34:21 | 13 | 36 |
| 7 |
|
Gimnasia y Esgrima (CdU) | 22 | 10 | 5 | 7 | 25:21 | 4 | 35 |
| 8 |
|
Sportivo Las Parejas | 23 | 9 | 7 | 7 | 24:20 | 4 | 34 |
| 9 |
|
Belgrano de San Francisco | 23 | 9 | 5 | 9 | 30:27 | 3 | 32 |
| 10 |
|
Crucero del Norte | 23 | 7 | 7 | 9 | 18:29 | -11 | 28 |
| 11 |
|
Juventud Antoniana | 23 | 7 | 6 | 10 | 20:28 | -8 | 27 |
| 12 |
|
Defensores Belgrano (VR) | 23 | 6 | 5 | 12 | 19:26 | -7 | 23 |
| 13 |
|
Boca Unidos | 22 | 4 | 9 | 9 | 18:25 | -7 | 21 |
| 14 |
|
Unión de Sunchales | 22 | 5 | 4 | 13 | 22:37 | -15 | 19 |
| 15 |
|
Atlético Paraná | 23 | 4 | 7 | 12 | 18:33 | -15 | 19 |
| 16 |
|
Defensores de Pronunciamiento | 22 | 3 | 8 | 11 | 13:31 | -18 | 17 |
| 17 |
|
Juventud Unida de Gualeguaychú | 22 | 4 | 4 | 14 | 18:42 | -24 | 16 |
| Play-offs |
