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| 20.08.2022 | 19:00 | Defensores de Pronunciamiento | - | Atlético Paraná | 2:0 (1:0) | |
| 20:00 | Douglas Haig | - | Boca Unidos | 1:1 (1:1) | ||
| 20:00 | Belgrano de San Francisco | - | Gimnasia y Esgrima (CdU) | 3:1 (0:0) | ||
| 20:30 | Defensores Belgrano (VR) | - | Juventud Antoniana | 2:3 (1:0) | ||
| 21:00 | San Martín de Formosa | - | Sportivo Las Parejas | 4:2 (1:0) | ||
| 21:00 | Sarmiento de Resistencia | - | Juventud Unida de Gualeguaychú | 2:1 (1:0) | ||
| 21.08.2022 | 01:00 | Unión de Sunchales | - | Gimnasia y Tiro de Salta | 0:0 (0:0) | |
| 03:00 | Central Norte | - | Crucero del Norte | 2:0 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing de Córdoba | 23 | 14 | 8 | 1 | 42:12 | 30 | 50 |
| 2 |
|
Sarmiento de Resistencia | 24 | 14 | 8 | 2 | 36:13 | 23 | 50 |
| 3 |
|
San Martín de Formosa | 23 | 13 | 5 | 5 | 43:23 | 20 | 44 |
| 4 |
|
Central Norte | 23 | 12 | 8 | 3 | 33:17 | 16 | 44 |
| 5 |
|
Gimnasia y Tiro de Salta | 24 | 11 | 5 | 8 | 22:25 | -3 | 38 |
| 6 |
|
Douglas Haig | 24 | 10 | 7 | 7 | 35:22 | 13 | 37 |
| 7 |
|
Belgrano de San Francisco | 24 | 10 | 5 | 9 | 33:28 | 5 | 35 |
| 8 |
|
Gimnasia y Esgrima (CdU) | 23 | 10 | 5 | 8 | 26:24 | 2 | 35 |
| 9 |
|
Sportivo Las Parejas | 24 | 9 | 7 | 8 | 26:24 | 2 | 34 |
| 10 |
|
Juventud Antoniana | 24 | 8 | 6 | 10 | 23:30 | -7 | 30 |
| 11 |
|
Crucero del Norte | 24 | 7 | 7 | 10 | 18:31 | -13 | 28 |
| 12 |
|
Defensores Belgrano (VR) | 24 | 6 | 5 | 13 | 21:29 | -8 | 23 |
| 13 |
|
Boca Unidos | 23 | 4 | 10 | 9 | 19:26 | -7 | 22 |
| 14 |
|
Unión de Sunchales | 23 | 5 | 5 | 13 | 22:37 | -15 | 20 |
| 15 |
|
Defensores de Pronunciamiento | 23 | 4 | 8 | 11 | 15:31 | -16 | 20 |
| 16 |
|
Atlético Paraná | 24 | 4 | 7 | 13 | 18:35 | -17 | 19 |
| 17 |
|
Juventud Unida de Gualeguaychú | 23 | 4 | 4 | 15 | 19:44 | -25 | 16 |
| Play-offs |
