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| 08.10.2022 | 22:00 | Crucero del Norte | - | Juventud Antoniana | 2:0 (1:0) | |
| 09.10.2022 | 00:00 | Atlético Paraná | - | Juventud Unida de Gualeguaychú | 2:0 (0:0) | |
| 21:00 | Defensores de Pronunciamiento | - | Belgrano de San Francisco | 0:2 (0:0) | ||
| 21:00 | Gimnasia y Tiro de Salta | - | Gimnasia y Esgrima (CdU) | 3:0 (1:0) | ||
| 21:00 | Sportivo Las Parejas | - | Boca Unidos | 0:0 (0:0) | ||
| 21:30 | San Martín de Formosa | - | Sarmiento de Resistencia | 1:0 (0:0) | ||
| 23:00 | Central Norte | - | Douglas Haig | 1:1 (0:1) | ||
| 11.10.2022 | 02:00 | Unión de Sunchales | - | Racing de Córdoba | 1:1 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing de Córdoba | 31 | 19 | 10 | 2 | 51:15 | 36 | 67 |
| 2 |
|
Sarmiento de Resistencia | 31 | 18 | 9 | 4 | 42:17 | 25 | 63 |
| 3 |
|
San Martín de Formosa | 31 | 17 | 7 | 7 | 55:29 | 26 | 58 |
| 4 |
|
Central Norte | 31 | 15 | 11 | 5 | 44:25 | 19 | 56 |
| 5 |
|
Gimnasia y Tiro de Salta | 31 | 15 | 8 | 8 | 34:29 | 5 | 53 |
| 6 |
|
Douglas Haig | 31 | 13 | 8 | 10 | 41:31 | 10 | 47 |
| 7 |
|
Belgrano de San Francisco | 31 | 13 | 6 | 12 | 40:34 | 6 | 45 |
| 8 |
|
Sportivo Las Parejas | 31 | 11 | 10 | 10 | 32:33 | -1 | 43 |
| 9 |
|
Gimnasia y Esgrima (CdU) | 31 | 12 | 5 | 14 | 29:38 | -9 | 41 |
| 10 |
|
Crucero del Norte | 31 | 11 | 7 | 13 | 26:40 | -14 | 40 |
| 11 |
|
Juventud Antoniana | 32 | 11 | 7 | 14 | 34:41 | -7 | 40 |
| 12 |
|
Boca Unidos | 31 | 7 | 13 | 11 | 29:34 | -5 | 34 |
| 13 |
|
Defensores de Pronunciamiento | 31 | 7 | 9 | 15 | 25:38 | -13 | 30 |
| 14 |
|
Unión de Sunchales | 31 | 8 | 6 | 17 | 30:47 | -17 | 30 |
| 15 |
|
Defensores Belgrano (VR) | 31 | 8 | 5 | 18 | 24:37 | -13 | 29 |
| 16 |
|
Atlético Paraná | 31 | 6 | 8 | 17 | 24:44 | -20 | 26 |
| 17 |
|
Juventud Unida de Gualeguaychú | 31 | 6 | 5 | 20 | 27:55 | -28 | 23 |
| Play-offs |
