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| 02.10.2021 | 11:00 | FC Carl Zeiss Jena | - | VfL Wolfsburg | 1:1 (1:1) | |
| 11:00 | Hansa Rostock | - | Werder Bremen | 2:0 (1:0) | ||
| 11:00 | Hertha Zehlendorf | - | Holstein Kiel | 2:0 (1:0) | ||
| 12:00 | Dynamo Dresden | - | RB Leipzig | 1:2 (0:0) | ||
| 12:00 | 1. FC Union Berlin | - | Energie Cottbus | 3:1 (1:1) | ||
| 13:00 | Hannover 96 | - | FC St. Pauli | 0:0 (0:0) | ||
| 14:00 | Chemnitzer FC | - | Eintracht Braunschweig | 2:1 (0:1) | ||
| 14:00 | FC Viktoria 1889 Berlin | - | Erzgebirge Aue | 1:0 (0:0) | ||
| 04.12.2021 | 14:00 | Hallescher FC | - | Hertha BSC | 0:3 (0:2) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Hertha BSC | 7 | 7 | 0 | 0 | 23:2 | 21 | 21 |
| 2 |
|
Hannover 96 | 6 | 5 | 1 | 0 | 10:4 | 6 | 16 |
| 3 |
|
VfL Wolfsburg | 7 | 4 | 3 | 0 | 16:8 | 8 | 15 |
| 4 |
|
Chemnitzer FC | 7 | 5 | 0 | 2 | 8:8 | 0 | 15 |
| 5 |
|
FC St. Pauli | 7 | 4 | 1 | 2 | 18:5 | 13 | 13 |
| 6 |
|
Dynamo Dresden | 6 | 4 | 0 | 2 | 12:5 | 7 | 12 |
| 7 |
|
1. FC Union Berlin | 7 | 4 | 0 | 3 | 11:5 | 6 | 12 |
| 8 |
|
RB Leipzig | 7 | 4 | 0 | 3 | 9:9 | 0 | 12 |
| 9 |
|
Hamburger SV | 6 | 3 | 1 | 2 | 13:8 | 5 | 10 |
| 10 |
|
FC Viktoria 1889 Berlin | 6 | 3 | 0 | 3 | 9:9 | 0 | 9 |
| 11 |
|
Werder Bremen | 6 | 3 | 0 | 3 | 12:13 | -1 | 9 |
| 12 |
|
Hansa Rostock | 7 | 2 | 2 | 3 | 9:13 | -4 | 8 |
| 13 |
|
Erzgebirge Aue | 7 | 2 | 1 | 4 | 5:9 | -4 | 7 |
| 14 |
|
Holstein Kiel | 6 | 2 | 0 | 4 | 8:15 | -7 | 6 |
| 15 |
|
Eintracht Braunschweig | 6 | 1 | 1 | 4 | 6:12 | -6 | 4 |
| 16 |
|
FC Carl Zeiss Jena | 7 | 1 | 1 | 5 | 3:13 | -10 | 4 |
| 17 |
|
Hallescher FC | 7 | 1 | 1 | 5 | 6:25 | -19 | 4 |
| 18 |
|
Hertha Zehlendorf | 7 | 1 | 0 | 6 | 8:13 | -5 | 3 |
| 19 |
|
Energie Cottbus | 7 | 1 | 0 | 6 | 7:17 | -10 | 3 |
| Play-offs | |
| Degradatie |
