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| 20.08.2021 | 18:30 | 1. FC Kaiserslautern | - | 1899 Hoffenheim | 5:0 (2:0) | |
| 21.08.2021 | 11:00 | FC Augsburg | - | FSV Frankfurt | 0:2 (0:1) | |
| 12:00 | Eintracht Frankfurt | - | SV Wehen Wiesbaden | 3:0 (1:0) | ||
| 12:30 | SpVgg Greuther Fürth | - | SpVgg Unterhaching | 1:2 (1:2) | ||
| 15:00 | SC Freiburg | - | SV 07 Elversberg | 4:0 (2:0) | ||
| 15:30 | 1. FC Heidenheim 1846 | - | TSV 1860 München | 2:2 (2:0) | ||
| 22.08.2021 | 11:00 | FC Ingolstadt 04 | - | 1. FSV Mainz 05 | 0:4 (0:2) | |
| 13:00 | SV Darmstadt 98 | - | Karlsruher SC | 2:1 (0:0) | ||
| 13:00 | Stuttgarter Kickers | - | 1. FC Nürnberg | 3:2 (1:0) | ||
| 14:00 | SSV Reutlingen | - | VfB Stuttgart | 0:6 (0:5) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Freiburg | 2 | 2 | 0 | 0 | 6:0 | 6 | 6 |
| 2 |
|
SpVgg Unterhaching | 2 | 2 | 0 | 0 | 6:3 | 3 | 6 |
| 3 |
|
FSV Frankfurt | 2 | 2 | 0 | 0 | 4:1 | 3 | 6 |
| 4 |
|
VfB Stuttgart | 2 | 1 | 1 | 0 | 7:1 | 6 | 4 |
| 5 |
|
1. FSV Mainz 05 | 2 | 1 | 1 | 0 | 6:2 | 4 | 4 |
| 6 |
|
Eintracht Frankfurt | 2 | 1 | 1 | 0 | 4:1 | 3 | 4 |
| 7 |
|
TSV 1860 München | 2 | 1 | 1 | 0 | 5:4 | 1 | 4 |
| 8 |
|
1. FC Kaiserslautern | 2 | 1 | 0 | 1 | 7:3 | 4 | 3 |
| 9 |
|
1. FC Nürnberg | 2 | 1 | 0 | 1 | 4:3 | 1 | 3 |
| 10 |
|
Stuttgarter Kickers | 2 | 1 | 0 | 1 | 4:4 | 0 | 3 |
| 11 |
|
1899 Hoffenheim | 2 | 1 | 0 | 1 | 4:6 | -2 | 3 |
| 12 |
|
SV 07 Elversberg | 2 | 1 | 0 | 1 | 3:5 | -2 | 3 |
|
SV Darmstadt 98 | 2 | 1 | 0 | 1 | 3:5 | -2 | 3 | |
| 14 |
|
1. FC Heidenheim 1846 | 1 | 0 | 1 | 0 | 2:2 | 0 | 1 |
| 15 |
|
SpVgg Greuther Fürth | 2 | 0 | 1 | 1 | 3:4 | -1 | 1 |
| 16 |
|
Karlsruher SC | 2 | 0 | 1 | 1 | 2:3 | -1 | 1 |
| 17 |
|
FC Ingolstadt 04 | 2 | 0 | 1 | 1 | 1:5 | -4 | 1 |
| 18 |
|
Bayern München | 1 | 0 | 0 | 1 | 0:2 | -2 | 0 |
| 19 |
|
FC Augsburg | 2 | 0 | 0 | 2 | 2:6 | -4 | 0 |
| 20 |
|
SV Wehen Wiesbaden | 2 | 0 | 0 | 2 | 0:5 | -5 | 0 |
| 21 |
|
SSV Reutlingen | 2 | 0 | 0 | 2 | 1:9 | -8 | 0 |
| Play-offs | |
| Degradatie |
