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| 21.03.2022 | 19:30 | Royal Excel Mouscron II | - | KV Oostende II | 0:1 | |
| 19:30 | KAS Eupen II | - | Union St. Gilloise II | 3:3 | ||
| 19:30 | KV Kortrijk II | - | K Beerschot VA II | 2:4 | ||
| 20:00 | Lommel SK II | - | SK Beveren II | 3:3 | ||
| 20:00 | Lierse Kempenzonen II | - | KVC Westerlo II | 2:0 | ||
| 20:00 | RFC Seraing II | - | RWDM Brussels FC II | 0:2 | ||
| 20:00 | SK Deinze II | - | Excelsior Virton II | 1:3 |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
K Beerschot VA II | 23 | 17 | 4 | 2 | 59:20 | 39 | 55 |
| 2 |
|
KAS Eupen II | 23 | 16 | 3 | 4 | 56:29 | 27 | 51 |
| 3 |
|
KV Oostende II | 23 | 13 | 7 | 3 | 54:27 | 27 | 46 |
| 4 |
|
Excelsior Virton II | 23 | 12 | 2 | 9 | 53:59 | -6 | 38 |
| 5 |
|
Royal Excel Mouscron II | 23 | 11 | 4 | 8 | 46:27 | 19 | 37 |
| 6 |
|
SK Beveren II | 23 | 11 | 2 | 10 | 40:28 | 12 | 35 |
| 7 |
|
Union St. Gilloise II | 23 | 10 | 5 | 8 | 34:26 | 8 | 35 |
| 8 |
|
RWDM Brussels FC II | 23 | 11 | 2 | 10 | 47:45 | 2 | 35 |
| 9 |
|
RFC Seraing II | 23 | 9 | 2 | 12 | 35:38 | -3 | 29 |
| 10 |
|
KVC Westerlo II | 23 | 8 | 2 | 13 | 34:42 | -8 | 26 |
| 11 |
|
Lierse Kempenzonen II | 23 | 7 | 4 | 12 | 27:53 | -26 | 25 |
| 12 |
|
SK Deinze II | 23 | 5 | 3 | 15 | 24:52 | -28 | 18 |
| 13 |
|
Lommel SK II | 23 | 4 | 4 | 15 | 23:57 | -34 | 16 |
| 14 |
|
KV Kortrijk II | 23 | 2 | 6 | 15 | 29:58 | -29 | 12 |
| Promotie |
