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| 05.02.2022 | 13:30 | SV Zulte Waregem | - | KVC Westerlo | 2:0 (0:0) | |
| 14:00 | Sporting Charleroi | - | Club Brugge KV | 0:3 (0:0) | ||
| 14:00 | Royal Antwerp FC | - | Oud-Heverlee Leuven | 2:3 (0:0) | ||
| 14:00 | Cercle Brugge | - | Standard Liège | 1:3 (0:0) | ||
| 14:30 | KAA Gent | - | RSC Anderlecht | 0:1 (0:0) | ||
| 14.05.2022 | 13:30 | KRC Genk | - | Sint-Truidense VV | 3:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KRC Genk | 17 | 13 | 2 | 2 | 64:22 | 42 | 41 |
| 2 |
|
Club Brugge KV | 17 | 12 | 4 | 1 | 51:19 | 32 | 40 |
| 3 |
|
RSC Anderlecht | 16 | 9 | 5 | 2 | 37:22 | 15 | 32 |
| 4 |
|
Standard Liège | 17 | 9 | 2 | 6 | 28:21 | 7 | 29 |
| 5 |
|
SV Zulte Waregem | 17 | 7 | 7 | 3 | 28:19 | 9 | 28 |
| 6 |
|
KAA Gent | 17 | 8 | 2 | 7 | 37:35 | 2 | 26 |
| 7 |
|
Sporting Charleroi | 17 | 6 | 5 | 6 | 23:29 | -6 | 23 |
| 8 |
|
KV Mechelen | 16 | 6 | 2 | 8 | 31:33 | -2 | 20 |
| 9 |
|
Sint-Truidense VV | 17 | 5 | 5 | 7 | 17:26 | -9 | 20 |
| 10 |
|
Oud-Heverlee Leuven | 16 | 5 | 3 | 8 | 24:38 | -14 | 18 |
| 11 |
|
Royal Antwerp FC | 16 | 4 | 1 | 11 | 15:26 | -11 | 13 |
| 12 |
|
Cercle Brugge | 17 | 3 | 3 | 11 | 28:60 | -32 | 12 |
| 13 |
|
KVC Westerlo | 16 | 0 | 1 | 15 | 11:44 | -33 | 1 |
