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| 26.03.2022 | 14:00 | Royal Antwerp FC | - | SV Zulte Waregem | 0:2 (0:0) | |
| 14:00 | Cercle Brugge | - | KV Mechelen | 4:1 (0:0) | ||
| 14:15 | KVC Westerlo | - | RSC Anderlecht | 2:3 (0:0) | ||
| 13.04.2022 | 12:30 | Oud-Heverlee Leuven | - | Club Brugge KV | 2:3 (0:0) | |
| 16.04.2022 | 13:30 | KRC Genk | - | Sporting Charleroi | 2:0 (0:0) | |
| 14:00 | Standard Liège | - | Sint-Truidense VV | 3:3 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KRC Genk | 23 | 19 | 2 | 2 | 84:29 | 55 | 59 |
| 2 |
|
Club Brugge KV | 22 | 16 | 4 | 2 | 67:29 | 38 | 52 |
| 3 |
|
RSC Anderlecht | 22 | 13 | 5 | 4 | 57:37 | 20 | 44 |
| 4 |
|
Standard Liège | 22 | 11 | 4 | 7 | 49:35 | 14 | 37 |
| 5 |
|
SV Zulte Waregem | 22 | 9 | 7 | 6 | 31:28 | 3 | 34 |
| 6 |
|
KAA Gent | 22 | 10 | 3 | 9 | 46:41 | 5 | 33 |
| 7 |
|
Sporting Charleroi | 22 | 8 | 5 | 9 | 31:38 | -7 | 29 |
| 8 |
|
KV Mechelen | 22 | 8 | 2 | 12 | 43:47 | -4 | 26 |
| 9 |
|
Sint-Truidense VV | 22 | 6 | 8 | 8 | 25:34 | -9 | 26 |
| 10 |
|
Oud-Heverlee Leuven | 22 | 6 | 5 | 11 | 37:53 | -16 | 23 |
| 11 |
|
Royal Antwerp FC | 22 | 7 | 1 | 14 | 25:42 | -17 | 22 |
| 12 |
|
Cercle Brugge | 23 | 5 | 4 | 14 | 43:79 | -36 | 19 |
| 13 |
|
KVC Westerlo | 22 | 0 | 2 | 20 | 20:66 | -46 | 2 |
