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| U | Nacional Potosí | - | Blooming | 3:1 (2:1) | ||
| R | Blooming | - | Nacional Potosí | 5:3 (1:0, 2:0, 2:0) d.p. | ||
| U: 28.05.2022 21:00 | R: 03.06.2022 02:00 | Winnaars: Blooming | ||||
| U | Always Ready | - | Atlético Palmaflor | 2:1 (1:0) | ||
| R | Atlético Palmaflor | - | Always Ready | 5:4 (0:0, 2:1, 2:1) d.p. | ||
| U: 29.05.2022 21:00 | R: 01.06.2022 22:00 | Winnaars: Atlético Palmaflor | ||||
| U | Royal Pari | - | The Strongest | 0:3 (0:1) | ||
| R | The Strongest | - | Royal Pari | 4:0 (1:0) | ||
| U: 30.05.2022 00:00 | R: 02.06.2022 02:30 | Winnaars: The Strongest | ||||
| U | Oriente Petrolero | - | Bolívar | 1:0 (1:0) | ||
| R | Bolívar | - | Oriente Petrolero | 7:6 (0:0, 1:0, 1:0) d.p. | ||
| U: 30.05.2022 01:30 | R: 03.06.2022 02:00 | Winnaars: Bolívar | ||||
