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| 09.10.2021 | 21:30 | Atlético Mineiro | - | Ceará - CE | 3:1 (2:0) | |
| 21:30 | Fluminense RJ | - | Atlético Goianiense | 0:0 (0:0) | ||
| 21:30 | Sport Recife - PE | - | Corinthians SP | 1:0 (0:0) | ||
| 10.10.2021 | 00:00 | Athletico Paranaense | - | Bahia - BA | 0:2 (0:1) | |
| 00:00 | Fortaleza | - | Flamengo RJ | 0:3 (0:0) | ||
| 02:00 | Juventude - RS | - | América - MG | 1:1 (1:1) | ||
| 02:00 | Palmeiras | - | Red Bull Bragantino | 2:4 (1:3) | ||
| 16:00 | Internacional | - | Chapecoense | 5:2 (4:0) | ||
| 21:00 | Santos FC | - | Grêmio Porto Alegre | 1:0 (0:0) | ||
| 12.10.2021 | 01:00 | Cuiabá - MT | - | São Paulo FC | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético Mineiro | 25 | 17 | 5 | 3 | 40:17 | 23 | 56 |
| 2 |
|
Flamengo RJ | 25 | 14 | 5 | 6 | 49:24 | 25 | 47 |
| 3 |
|
Palmeiras | 25 | 13 | 3 | 9 | 39:33 | 6 | 42 |
| 4 |
|
Fortaleza | 25 | 11 | 6 | 8 | 32:29 | 3 | 39 |
| 5 |
|
Red Bull Bragantino | 25 | 9 | 12 | 4 | 40:30 | 10 | 39 |
| 6 |
|
Internacional | 25 | 9 | 10 | 6 | 32:26 | 6 | 37 |
| 7 |
|
Corinthians SP | 25 | 9 | 10 | 6 | 27:23 | 4 | 37 |
| 8 |
|
Athletico Paranaense | 25 | 10 | 4 | 11 | 33:33 | 0 | 34 |
| 9 |
|
Fluminense RJ | 25 | 8 | 9 | 8 | 24:28 | -4 | 33 |
| 10 |
|
América - MG | 25 | 7 | 10 | 8 | 24:26 | -2 | 31 |
| 11 |
|
Atlético Goianiense | 25 | 7 | 10 | 8 | 20:24 | -4 | 31 |
| 12 |
|
Santos FC | 25 | 7 | 10 | 8 | 24:29 | -5 | 31 |
| 13 |
|
Cuiabá - MT | 25 | 6 | 13 | 6 | 25:26 | -1 | 31 |
| 14 |
|
Ceará - CE | 25 | 6 | 12 | 7 | 23:27 | -4 | 30 |
| 15 |
|
São Paulo FC | 25 | 6 | 12 | 7 | 20:25 | -5 | 30 |
| 16 |
|
Juventude - RS | 25 | 6 | 10 | 9 | 24:30 | -6 | 28 |
| 17 |
|
Bahia - BA | 25 | 7 | 6 | 12 | 29:39 | -10 | 27 |
| 18 |
|
Sport Recife - PE | 25 | 6 | 8 | 11 | 14:21 | -7 | 26 |
| 19 |
|
Grêmio Porto Alegre | 25 | 6 | 6 | 13 | 23:31 | -8 | 24 |
| 20 |
|
Chapecoense | 25 | 1 | 9 | 15 | 22:43 | -21 | 12 |
| Copa Libertadores | |
| Kwalificatie | |
| Copa Sudamericana | |
| Degradatie |
