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| U | Atlético Cearense - CE | - | Campinense - PB | 1:1 (0:0) | ||
| R | Campinense - PB | - | Atlético Cearense - CE | 3:1 (1:1) | ||
| U: 23.10.2021 20:00 | R: 30.10.2021 21:00 | Winnaars: Campinense - PB | ||||
| U | Aparecidense - GO | - | ABC - RN | 4:2 (1:1) | ||
| R | ABC - RN | - | Aparecidense - GO | 1:0 (1:0) | ||
| U: 24.10.2021 21:00 | R: 31.10.2021 20:00 | Winnaars: Aparecidense - GO | ||||
