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| 10.12.2021 | 20:30 | 1. FC Köln | - | FC Augsburg | 0:2 (0:0) | |
| 11.12.2021 | 15:30 | Bayern München | - | 1. FSV Mainz 05 | 2:1 (0:1) | |
| 15:30 | RB Leipzig | - | Bor. Mönchengladbach | 4:1 (2:0) | ||
| 15:30 | SC Freiburg | - | 1899 Hoffenheim | 1:2 (1:1) | ||
| 15:30 | Hertha BSC | - | Arminia Bielefeld | 2:0 (0:0) | ||
| 15:30 | VfL Bochum | - | Borussia Dortmund | 1:1 (1:0) | ||
| 18:30 | VfL Wolfsburg | - | VfB Stuttgart | 0:2 (0:1) | ||
| 12.12.2021 | 15:30 | SpVgg Greuther Fürth | - | 1. FC Union Berlin | 1:0 (0:0) | |
| 17:30 | Eintracht Frankfurt | - | Bayer Leverkusen | 5:2 (2:2) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 15 | 12 | 1 | 2 | 47:16 | 31 | 37 |
| 2 |
|
Borussia Dortmund | 15 | 10 | 1 | 4 | 36:23 | 13 | 31 |
| 3 |
|
Bayer Leverkusen | 15 | 8 | 3 | 4 | 37:24 | 13 | 27 |
| 4 |
|
1899 Hoffenheim | 15 | 8 | 2 | 5 | 32:23 | 9 | 26 |
| 5 |
|
SC Freiburg | 15 | 7 | 4 | 4 | 26:15 | 11 | 25 |
| 6 |
|
1. FC Union Berlin | 15 | 6 | 5 | 4 | 22:21 | 1 | 23 |
| 7 |
|
RB Leipzig | 15 | 6 | 3 | 6 | 29:19 | 10 | 21 |
| 8 |
|
1. FSV Mainz 05 | 15 | 6 | 3 | 6 | 21:16 | 5 | 21 |
| 9 |
|
Eintracht Frankfurt | 15 | 5 | 6 | 4 | 23:22 | 1 | 21 |
| 10 |
|
VfL Bochum | 15 | 6 | 2 | 7 | 16:23 | -7 | 20 |
| 11 |
|
VfL Wolfsburg | 15 | 6 | 2 | 7 | 15:22 | -7 | 20 |
| 12 |
|
1. FC Köln | 15 | 4 | 7 | 4 | 23:25 | -2 | 19 |
| 13 |
|
Bor. Mönchengladbach | 15 | 5 | 3 | 7 | 19:28 | -9 | 18 |
| 14 |
|
Hertha BSC | 15 | 5 | 3 | 7 | 17:29 | -12 | 18 |
| 15 |
|
VfB Stuttgart | 15 | 4 | 5 | 6 | 22:25 | -3 | 17 |
| 16 |
|
FC Augsburg | 15 | 4 | 4 | 7 | 16:25 | -9 | 16 |
| 17 |
|
Arminia Bielefeld | 15 | 1 | 7 | 7 | 10:22 | -12 | 10 |
| 18 |
|
SpVgg Greuther Fürth | 15 | 1 | 1 | 13 | 13:46 | -33 | 4 |
| Champions League | |
| Europa League | |
| Promotie en degradatie | |
| Degradatie |
