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| 07.01.2022 | 20:30 | Bayern München | - | Bor. Mönchengladbach | 1:2 (1:2) | |
| 08.01.2022 | 15:30 | Bayer Leverkusen | - | 1. FC Union Berlin | 2:2 (1:1) | |
| 15:30 | SpVgg Greuther Fürth | - | VfB Stuttgart | 0:0 (0:0) | ||
| 15:30 | RB Leipzig | - | 1. FSV Mainz 05 | 4:1 (1:0) | ||
| 15:30 | 1899 Hoffenheim | - | FC Augsburg | 3:1 (2:1) | ||
| 15:30 | SC Freiburg | - | Arminia Bielefeld | 2:2 (1:0) | ||
| 18:30 | Eintracht Frankfurt | - | Borussia Dortmund | 2:3 (2:0) | ||
| 09.01.2022 | 15:30 | Hertha BSC | - | 1. FC Köln | 1:3 (0:2) | |
| 17:30 | VfL Bochum | - | VfL Wolfsburg | 1:0 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 18 | 14 | 1 | 3 | 57:18 | 39 | 43 |
| 2 |
|
Borussia Dortmund | 18 | 12 | 1 | 5 | 44:28 | 16 | 37 |
| 3 |
|
1899 Hoffenheim | 18 | 9 | 4 | 5 | 38:27 | 11 | 31 |
| 4 |
|
SC Freiburg | 18 | 8 | 6 | 4 | 30:18 | 12 | 30 |
| 5 |
|
Bayer Leverkusen | 18 | 8 | 5 | 5 | 42:30 | 12 | 29 |
| 6 |
|
1. FC Köln | 18 | 7 | 7 | 4 | 30:28 | 2 | 28 |
| 7 |
|
1. FC Union Berlin | 18 | 7 | 7 | 4 | 25:23 | 2 | 28 |
| 8 |
|
Eintracht Frankfurt | 18 | 7 | 6 | 5 | 29:27 | 2 | 27 |
| 9 |
|
RB Leipzig | 18 | 7 | 4 | 7 | 34:23 | 11 | 25 |
| 10 |
|
1. FSV Mainz 05 | 18 | 7 | 3 | 8 | 26:21 | 5 | 24 |
| 11 |
|
VfL Bochum | 18 | 7 | 2 | 9 | 17:26 | -9 | 23 |
| 12 |
|
Bor. Mönchengladbach | 18 | 6 | 4 | 8 | 24:33 | -9 | 22 |
| 13 |
|
Hertha BSC | 18 | 6 | 3 | 9 | 21:38 | -17 | 21 |
| 14 |
|
VfL Wolfsburg | 18 | 6 | 2 | 10 | 17:30 | -13 | 20 |
| 15 |
|
VfB Stuttgart | 18 | 4 | 6 | 8 | 22:31 | -9 | 18 |
| 16 |
|
FC Augsburg | 18 | 4 | 6 | 8 | 18:29 | -11 | 18 |
| 17 |
|
Arminia Bielefeld | 18 | 3 | 8 | 7 | 16:24 | -8 | 17 |
| 18 |
|
SpVgg Greuther Fürth | 18 | 1 | 3 | 14 | 13:49 | -36 | 6 |
| Champions League | |
| Europa League | |
| Promotie en degradatie | |
| Degradatie |
