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| 14.01.2022 | 20:30 | Borussia Dortmund | - | SC Freiburg | 5:1 (3:0) | |
| 15.01.2022 | 15:30 | 1. FC Köln | - | Bayern München | 0:4 (0:2) | |
| 15:30 | VfB Stuttgart | - | RB Leipzig | 0:2 (0:1) | ||
| 15:30 | 1. FC Union Berlin | - | 1899 Hoffenheim | 2:1 (1:1) | ||
| 15:30 | VfL Wolfsburg | - | Hertha BSC | 0:0 (0:0) | ||
| 15:30 | 1. FSV Mainz 05 | - | VfL Bochum | 1:0 (0:0) | ||
| 18:30 | Bor. Mönchengladbach | - | Bayer Leverkusen | 1:2 (0:0) | ||
| 16.01.2022 | 15:30 | FC Augsburg | - | Eintracht Frankfurt | 1:1 (1:1) | |
| 17:30 | Arminia Bielefeld | - | SpVgg Greuther Fürth | 2:2 (1:1) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 19 | 15 | 1 | 3 | 61:18 | 43 | 46 |
| 2 |
|
Borussia Dortmund | 19 | 13 | 1 | 5 | 49:29 | 20 | 40 |
| 3 |
|
Bayer Leverkusen | 19 | 9 | 5 | 5 | 44:31 | 13 | 32 |
| 4 |
|
1899 Hoffenheim | 19 | 9 | 4 | 6 | 39:29 | 10 | 31 |
| 5 |
|
1. FC Union Berlin | 19 | 8 | 7 | 4 | 27:24 | 3 | 31 |
| 6 |
|
SC Freiburg | 19 | 8 | 6 | 5 | 31:23 | 8 | 30 |
| 7 |
|
RB Leipzig | 19 | 8 | 4 | 7 | 36:23 | 13 | 28 |
| 8 |
|
Eintracht Frankfurt | 19 | 7 | 7 | 5 | 30:28 | 2 | 28 |
| 9 |
|
1. FC Köln | 19 | 7 | 7 | 5 | 30:32 | -2 | 28 |
| 10 |
|
1. FSV Mainz 05 | 19 | 8 | 3 | 8 | 27:21 | 6 | 27 |
| 11 |
|
VfL Bochum | 19 | 7 | 2 | 10 | 17:27 | -10 | 23 |
| 12 |
|
Bor. Mönchengladbach | 19 | 6 | 4 | 9 | 25:35 | -10 | 22 |
| 13 |
|
Hertha BSC | 19 | 6 | 4 | 9 | 21:38 | -17 | 22 |
| 14 |
|
VfL Wolfsburg | 19 | 6 | 3 | 10 | 17:30 | -13 | 21 |
| 15 |
|
FC Augsburg | 19 | 4 | 7 | 8 | 19:30 | -11 | 19 |
| 16 |
|
Arminia Bielefeld | 19 | 3 | 9 | 7 | 18:26 | -8 | 18 |
| 17 |
|
VfB Stuttgart | 19 | 4 | 6 | 9 | 22:33 | -11 | 18 |
| 18 |
|
SpVgg Greuther Fürth | 19 | 1 | 4 | 14 | 15:51 | -36 | 7 |
| Champions League | |
| Europa League | |
| Promotie en degradatie | |
| Degradatie |
