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| 25.02.2022 | 20:30 | 1899 Hoffenheim | - | VfB Stuttgart | 2:1 (0:0) | |
| 26.02.2022 | 15:30 | Bor. Mönchengladbach | - | VfL Wolfsburg | 2:2 (1:2) | |
| 15:30 | 1. FC Union Berlin | - | 1. FSV Mainz 05 | 3:1 (1:0) | ||
| 15:30 | SC Freiburg | - | Hertha BSC | 3:0 (1:0) | ||
| 15:30 | Bayer Leverkusen | - | Arminia Bielefeld | 3:0 (1:0) | ||
| 15:30 | SpVgg Greuther Fürth | - | 1. FC Köln | 1:1 (0:0) | ||
| 18:30 | Eintracht Frankfurt | - | Bayern München | 0:1 (0:0) | ||
| 27.02.2022 | 15:30 | VfL Bochum | - | RB Leipzig | 0:1 (0:0) | |
| 17:30 | FC Augsburg | - | Borussia Dortmund | 1:1 (0:1) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 24 | 19 | 1 | 4 | 75:26 | 49 | 58 |
| 2 |
|
Borussia Dortmund | 24 | 16 | 2 | 6 | 64:37 | 27 | 50 |
| 3 |
|
Bayer Leverkusen | 24 | 13 | 5 | 6 | 63:39 | 24 | 44 |
| 4 |
|
RB Leipzig | 24 | 12 | 4 | 8 | 50:28 | 22 | 40 |
| 5 |
|
SC Freiburg | 24 | 11 | 7 | 6 | 39:26 | 13 | 40 |
| 6 |
|
1899 Hoffenheim | 24 | 12 | 4 | 8 | 47:36 | 11 | 40 |
| 7 |
|
1. FC Union Berlin | 24 | 10 | 7 | 7 | 32:32 | 0 | 37 |
| 8 |
|
1. FC Köln | 24 | 9 | 9 | 6 | 36:38 | -2 | 36 |
| 9 |
|
1. FSV Mainz 05 | 24 | 10 | 4 | 10 | 35:29 | 6 | 34 |
| 10 |
|
Eintracht Frankfurt | 24 | 8 | 7 | 9 | 33:36 | -3 | 31 |
| 11 |
|
VfL Bochum | 24 | 8 | 5 | 11 | 25:34 | -9 | 29 |
| 12 |
|
VfL Wolfsburg | 24 | 8 | 4 | 12 | 26:37 | -11 | 28 |
| 13 |
|
Bor. Mönchengladbach | 24 | 7 | 6 | 11 | 32:48 | -16 | 27 |
| 14 |
|
Arminia Bielefeld | 24 | 5 | 10 | 9 | 22:32 | -10 | 25 |
| 15 |
|
FC Augsburg | 24 | 5 | 8 | 11 | 26:41 | -15 | 23 |
| 16 |
|
Hertha BSC | 24 | 6 | 5 | 13 | 25:54 | -29 | 23 |
| 17 |
|
VfB Stuttgart | 24 | 4 | 7 | 13 | 28:45 | -17 | 19 |
| 18 |
|
SpVgg Greuther Fürth | 24 | 3 | 5 | 16 | 22:62 | -40 | 14 |
| Champions League | |
| Europa League | |
| Promotie en degradatie | |
| Degradatie |
