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| 06.05.2022 | 20:30 | VfL Bochum | - | Arminia Bielefeld | 2:1 (1:1) | |
| 07.05.2022 | 15:30 | SpVgg Greuther Fürth | - | Borussia Dortmund | 1:3 (0:1) | |
| 15:30 | 1. FC Köln | - | VfL Wolfsburg | 0:1 (0:1) | ||
| 15:30 | 1899 Hoffenheim | - | Bayer Leverkusen | 2:4 (2:1) | ||
| 15:30 | SC Freiburg | - | 1. FC Union Berlin | 1:4 (0:3) | ||
| 18:30 | Hertha BSC | - | 1. FSV Mainz 05 | 1:2 (1:1) | ||
| 08.05.2022 | 15:30 | Eintracht Frankfurt | - | Bor. Mönchengladbach | 1:1 (0:1) | |
| 17:30 | Bayern München | - | VfB Stuttgart | 2:2 (2:1) | ||
| 19:30 | RB Leipzig | - | FC Augsburg | 4:0 (1:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 33 | 24 | 4 | 5 | 95:35 | 60 | 76 |
| 2 |
|
Borussia Dortmund | 33 | 21 | 3 | 9 | 83:51 | 32 | 66 |
| 3 |
|
Bayer Leverkusen | 33 | 18 | 7 | 8 | 78:46 | 32 | 61 |
| 4 |
|
RB Leipzig | 33 | 17 | 6 | 10 | 71:36 | 35 | 57 |
| 5 |
|
SC Freiburg | 33 | 15 | 10 | 8 | 57:44 | 13 | 55 |
| 6 |
|
1. FC Union Berlin | 33 | 15 | 9 | 9 | 47:42 | 5 | 54 |
| 7 |
|
1. FC Köln | 33 | 14 | 10 | 9 | 51:47 | 4 | 52 |
| 8 |
|
1899 Hoffenheim | 33 | 13 | 7 | 13 | 57:55 | 2 | 46 |
| 9 |
|
1. FSV Mainz 05 | 33 | 13 | 6 | 14 | 48:43 | 5 | 45 |
| 10 |
|
Bor. Mönchengladbach | 33 | 11 | 9 | 13 | 49:60 | -11 | 42 |
| 11 |
|
VfL Bochum | 33 | 12 | 6 | 15 | 36:49 | -13 | 42 |
| 12 |
|
Eintracht Frankfurt | 33 | 10 | 11 | 12 | 43:47 | -4 | 41 |
| 13 |
|
VfL Wolfsburg | 33 | 12 | 5 | 16 | 41:52 | -11 | 41 |
| 14 |
|
FC Augsburg | 33 | 9 | 8 | 16 | 37:55 | -18 | 35 |
| 15 |
|
Hertha BSC | 33 | 9 | 6 | 18 | 36:69 | -33 | 33 |
| 16 |
|
VfB Stuttgart | 33 | 6 | 12 | 15 | 39:58 | -19 | 30 |
| 17 |
|
Arminia Bielefeld | 33 | 5 | 12 | 16 | 26:52 | -26 | 27 |
| 18 |
|
SpVgg Greuther Fürth | 33 | 3 | 9 | 21 | 27:80 | -53 | 18 |
| Champions League | |
| Europa League | |
| Promotie en degradatie | |
| Degradatie |
