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| U | Manchester City | - | Real Madrid | 4:3 (2:1) | ||
| R | Real Madrid | - | Manchester City | 3:1 (0:0, 2:1) n.v. | ||
| U: 26.04.2022 21:00 | R: 04.05.2022 21:00 | Winnaars: Real Madrid | ||||
| U | Liverpool FC | - | Villarreal CF | 2:0 (0:0) | ||
| R | Villarreal CF | - | Liverpool FC | 2:3 (2:0) | ||
| U: 27.04.2022 21:00 | R: 03.05.2022 21:00 | Winnaars: Liverpool FC | ||||
