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| U | Malmö FF | - | Rangers FC | 2:1 (0:0) | ||
| R | Rangers FC | - | Malmö FF | 1:2 (1:0) | ||
| U: 03.08.2021 19:00 | R: 10.08.2021 21:00 | Winnaars: Malmö FF | ||||
| U | Sparta Praag | - | AS Monaco | 0:2 (0:1) | ||
| R | AS Monaco | - | Sparta Praag | 3:1 (0:0) | ||
| U: 03.08.2021 19:00 | R: 10.08.2021 20:00 | Winnaars: AS Monaco | ||||
| U | CFR Cluj | - | BSC Young Boys | 1:1 (1:0) | ||
| R | BSC Young Boys | - | CFR Cluj | 3:1 (3:1) | ||
| U: 03.08.2021 20:00 | R: 10.08.2021 20:30 | Winnaars: BSC Young Boys | ||||
| U | PSV | - | FC Midtjylland | 3:0 (3:0) | ||
| R | FC Midtjylland | - | PSV | 0:1 (0:0) | ||
| U: 03.08.2021 20:00 | R: 10.08.2021 20:00 | Winnaars: PSV | ||||
| U | KRC Genk | - | Shakhtar Donetsk | 1:2 (1:0) | ||
| R | Shakhtar Donetsk | - | KRC Genk | 2:1 (1:0) | ||
| U: 03.08.2021 20:00 | R: 10.08.2021 19:30 | Winnaars: Shakhtar Donetsk | ||||
| U | Olympiakos | - | PFC Ludogorets Razgrad | 1:1 (0:0) | ||
| R | PFC Ludogorets Razgrad | - | Olympiakos | 4:1 (0:1, 2:2, 2:2) d.p. | ||
| U: 03.08.2021 21:00 | R: 10.08.2021 20:00 | Winnaars: PFC Ludogorets Razgrad | ||||
| U | Rode Ster Belgrado | - | FC Sheriff | 1:1 (1:1) | ||
| R | FC Sheriff | - | Rode Ster Belgrado | 1:0 (1:0) | ||
| U: 03.08.2021 21:00 | R: 10.08.2021 19:00 | Winnaars: FC Sheriff | ||||
| U | Spartak Moskou | - | SL Benfica | 0:2 (0:0) | ||
| R | SL Benfica | - | Spartak Moskou | 2:0 (0:0) | ||
| U: 04.08.2021 19:00 | R: 10.08.2021 21:00 | Winnaars: SL Benfica | ||||
| U | Dinamo Zagreb | - | Legia Warschau | 1:1 (0:0) | ||
| R | Legia Warschau | - | Dinamo Zagreb | 0:1 (0:1) | ||
| U: 04.08.2021 20:00 | R: 10.08.2021 21:00 | Winnaars: Dinamo Zagreb | ||||
| U | Ferencvárosi TC | - | Slavia Praag | 2:0 (1:0) | ||
| R | Slavia Praag | - | Ferencvárosi TC | 1:0 (1:0) | ||
| U: 04.08.2021 20:00 | R: 10.08.2021 19:00 | Winnaars: Ferencvárosi TC | ||||
