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| U | Independiente Medellín | - | Deportes Tolima | 2:2 (0:1) | ||
| R | Deportes Tolima | - | Independiente Medellín | 0:2 (0:0) | ||
| U: 22.11.2018 01:00 | R: 26.11.2018 01:30 | Winnaars: Independiente Medellín | ||||
| U | Águilas Doradas | - | Atlético Junior | 2:3 (0:0) | ||
| R | Atlético Junior | - | Águilas Doradas | 1:1 (1:0) | ||
| U: 23.11.2018 01:45 | R: 25.11.2018 23:15 | Winnaars: Atlético Junior | ||||
