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| U | CF Monterrey | - | Cruz Azul | 1:0 (1:0) | ||
| R | Cruz Azul | - | CF Monterrey | 1:4 (1:3) | ||
| U: 12.08.2021 04:00 | R: 17.09.2021 04:00 | Winnaars: CF Monterrey | ||||
| U | CF América | - | Philadelphia Union | 2:0 (1:0) | ||
| R | Philadelphia Union | - | CF América | 0:2 (0:0) | ||
| U: 13.08.2021 04:00 | R: 16.09.2021 03:00 | Winnaars: CF América | ||||
